Oscillospira and related bacteria - From metagenomic species to metabolic features - PubMed

Affiliations

• PMID: 28028921
• DOI: 10.1111/1462-2920.13658

Oscillospira and related bacteria - From metagenomic species to metabolic features

Uri Gophna et al. Environ Microbiol. 2017 Mar.

Abstract

Oscillospira is an under-studied anaerobic bacterial genus from Clostridial cluster IV that has resisted cultivation for over a century since the first time it was observed. In recent years its 16S rRNA gene was identified in several human gut microbiota studies where it was often associated with interesting traits, especially leanness. However, very little is known about its metabolism or physiology. Here we used nearly complete genomes derived from shot-gun metagenomic data from the human gut to analyze Oscillospira and related bacteria. We used sequence similarity, gene neighbourhood information and manual metabolic pathway curation to decipher key metabolic features of this intriguing bacterial genus. We infer that Oscillospira species are butyrate producers, and at least some of them have the ability to utilize glucuronate, a common animal-derived sugar that is both produced by the human host and consumed by that host in diets rich in animal products. These findings could help explain diet-related inter-individual variation in faecal Oscillospira levels as well as the observation that the presence of this genus is reduced in diseases that involve inflammation.

Similar articles

• Oscillospira: a Central, Enigmatic Component of the Human Gut Microbiota.

  Konikoff T, Gophna U. Konikoff T, et al. Trends Microbiol. 2016 Jul;24(7):523-524. doi: 10.1016/j.tim.2016.02.015. Epub 2016 Mar 17. Trends Microbiol. 2016. PMID: 26996766

• Functional and Genomic Variation between Human-Derived Isolates of Lachnospiraceae Reveals Inter- and Intra-Species Diversity.

  Sorbara MT, Littmann ER, Fontana E, Moody TU, Kohout CE, Gjonbalaj M, Eaton V, Seok R, Leiner IM, Pamer EG. Sorbara MT, et al. Cell Host Microbe. 2020 Jul 8;28(1):134-146.e4. doi: 10.1016/j.chom.2020.05.005. Epub 2020 Jun 2. Cell Host Microbe. 2020. PMID: 32492369 Free PMC article.

• Faecalibacterium prausnitzii subspecies-level dysbiosis in the human gut microbiome underlying atopic dermatitis.

  Song H, Yoo Y, Hwang J, Na YC, Kim HS. Song H, et al. J Allergy Clin Immunol. 2016 Mar;137(3):852-60. doi: 10.1016/j.jaci.2015.08.021. Epub 2015 Oct 1. J Allergy Clin Immunol. 2016. PMID: 26431583

• Oscillospira - a candidate for the next-generation probiotics.

  Yang J, Li Y, Wen Z, Liu W, Meng L, Huang H. Yang J, et al. Gut Microbes. 2021 Jan-Dec;13(1):1987783. doi: 10.1080/19490976.2021.1987783. Gut Microbes. 2021. PMID: 34693878 Free PMC article. Review.

• Formation of propionate and butyrate by the human colonic microbiota.

  Louis P, Flint HJ. Louis P, et al. Environ Microbiol. 2017 Jan;19(1):29-41. doi: 10.1111/1462-2920.13589. Epub 2016 Dec 8. Environ Microbiol. 2017. PMID: 27928878 Review.

Cited by

• How being synanthropic affects the gut bacteriome and mycobiome: comparison of two mouse species with contrasting ecologies.

  Bendová B, Piálek J, Ďureje Ľ, Schmiedová L, Čížková D, Martin JF, Kreisinger J. Bendová B, et al. BMC Microbiol. 2020 Jul 6;20(1):194. doi: 10.1186/s12866-020-01859-8. BMC Microbiol. 2020. PMID: 32631223 Free PMC article.

• Combinatorial Effects of Soluble, Insoluble, and Organic Extracts from Jerusalem Artichokes on Gut Microbiota in Mice.

  Sasaki H, Lyu Y, Nakayama Y, Nakamura F, Watanabe A, Miyakawa H, Nakao Y, Shibata S. Sasaki H, et al. Microorganisms. 2020 Jun 24;8(6):954. doi: 10.3390/microorganisms8060954. Microorganisms. 2020. PMID: 32599833 Free PMC article.

• 16S rRNA Gene Sequencing Revealed Changes in Gut Microbiota Composition during Pregnancy and Lactation in Mice Model.

  Guo M, Cao X, Zhang K, Pan M, Wu Y, Langda S, Yang Y, Chen Y, Gui B, Ma B. Guo M, et al. Vet Sci. 2022 Apr 1;9(4):169. doi: 10.3390/vetsci9040169. Vet Sci. 2022. PMID: 35448667 Free PMC article.

• A Combined Supplement of Probiotic Strains AP-32, bv-77, and CP-9 Increased Akkermansia mucinphila and Reduced Non-Esterified Fatty Acids and Energy Metabolism in HFD-Induced Obese Rats.

  Liao CA, Huang CH, Ho HH, Chen JF, Kuo YW, Lin JH, Tsai SY, Tsai HY, Yeh YT. Liao CA, et al. Nutrients. 2022 Jan 26;14(3):527. doi: 10.3390/nu14030527. Nutrients. 2022. PMID: 35276886 Free PMC article.

• Association of suboptimal health status with intestinal microbiota in Chinese youths.

  Sun Q, Xu X, Zhang J, Sun M, Tian Q, Li Q, Cao W, Zhang X, Wang H, Liu J, Zhang J, Meng X, Wu L, Song M, Liu H, Wang W, Wang Y. Sun Q, et al. J Cell Mol Med. 2020 Jan;24(2):1837-1847. doi: 10.1111/jcmm.14880. Epub 2019 Dec 6. J Cell Mol Med. 2020. PMID: 31808612 Free PMC article.

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Ovid Technologies, Inc.
  • Wiley

• Other Literature Sources

  • The Lens - Patent Citations Database
  • scite Smart Citations