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Wiring visual systems: common and divergent mechanisms and principles - PubMed

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Wiring visual systems: common and divergent mechanisms and principles

Alex L Kolodkin et al. Curr Opin Neurobiol. 2017 Feb.

Abstract

The study of visual systems has a rich history, leading to the discovery and understanding of basic principles underlying the elaboration of neuronal connectivity. Recent work in model organisms such as fly, fish and mouse has yielded a wealth of new insights into visual system wiring. Here, we consider how axonal and dendritic patterning in columns and laminae influence synaptic partner selection in these model organisms. We highlight similarities and differences among disparate visual systems with the goal of identifying common and divergent principles for visual system wiring.

Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

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Conflict of interest statement

Conflict of Interest Statement

We declare no conflict of interest.

Alex Kolodkin & Robin Hiesinger

Figures

Fig. 1
Fig. 1

Adult vertebrate and fly visual system wiring. (A): Comparison of retina-to-brain connectivity based on retina output neurons and possible evolutionary relationships between vertebrate RGCs and fly R cells. (B) Comparison of vertebrate retina to the fly optic lobe based on similarities of functional connectivity.

Fig. 2
Fig. 2

Pre-specification and post-specification of synapses in vertebrate retinotectal connectivity versus fly retina-lamina connectivity

Fig. 3
Fig. 3

Development of layers/lamination in the vertebrate retina compared to the fly optic lobe. (A): early during vertebrate retina development, ACs start forming laminae, while RGC axons remain in a waiting layer. Between P12-P30 RGCs and BCs target pre-existing layers to form contacts. (B) During Drosophila visual system development, R1–R8 grow through the optic stalk into the lamina (R1–R6) and medulla (R7, R8) in a temporal wave. Early during puparium formation (P+15%) medulla layer development still exhibits a temporal gradient, but layer development synchronizes shortly thereafter.

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