Concise Review: MSC Adhesion Cascade-Insights into Homing and Transendothelial Migration - PubMed

Affiliations

• PMID: 28316123
• DOI: 10.1002/stem.2614

Review

Concise Review: MSC Adhesion Cascade-Insights into Homing and Transendothelial Migration

Franziska Nitzsche et al. Stem Cells. 2017 Jun.

Abstract

Mesenchymal stem cells (MSCs) are promising candidates for adult cell therapies in regenerative medicine. To fully exert their potential, efficient homing and migration toward lesion sites play an important role. Local transplantation deposits MSC in spatial proximity to the lesion, but often requires invasive procedures. Systemic administration routes are favored, but require the targeted extravasation of the circulating MSC at the site of injury. Transplanted MSC can indeed leave the blood flow and transmigrate through the endothelial barrier, and reach the lesion site. However, the underlying processes are not completely dissolved yet. Recent in vitro and in vivo research identified some key molecules scattered light on the extravasation mechanism. This review provides a detailed overview over the current knowledge of MSC transendothelial migration. We use the leukocyte extravasation process as a role model to build a comprehensive concept of MSC egress mechanisms from the blood stream and identified relevant similarities as well as important differences between the extravasation mechanisms. Stem Cells 2017;35:1446-1460.

Keywords: Cell adhesion molecules; Cell migration; Chemokine receptors; Integrins; Leukocytes; Mesenchymal stem cells; Stem/progenitor cell.

Similar articles

• Involvement of PI3K and ROCK signaling pathways in migration of bone marrow-derived mesenchymal stem cells through human brain microvascular endothelial cell monolayers.

  Lin MN, Shang DS, Sun W, Li B, Xu X, Fang WG, Zhao WD, Cao L, Chen YH. Lin MN, et al. Brain Res. 2013 Jun 4;1513:1-8. doi: 10.1016/j.brainres.2013.03.035. Epub 2013 Mar 30. Brain Res. 2013. PMID: 23548598

• Urokinase type plasminogen activator mediates Interleukin-17-induced peripheral blood mesenchymal stem cell motility and transendothelial migration.

  Krstić J, Obradović H, Jauković A, Okić-Đorđević I, Trivanović D, Kukolj T, Mojsilović S, Ilić V, Santibañez JF, Bugarski D. Krstić J, et al. Biochim Biophys Acta. 2015 Feb;1853(2):431-44. doi: 10.1016/j.bbamcr.2014.11.025. Epub 2014 Nov 27. Biochim Biophys Acta. 2015. PMID: 25433194

• Human mesenchymal stem cells target adhesion molecules and receptors involved in T cell extravasation.

  Benvenuto F, Voci A, Carminati E, Gualandi F, Mancardi G, Uccelli A, Vergani L. Benvenuto F, et al. Stem Cell Res Ther. 2015 Dec 10;6:245. doi: 10.1186/s13287-015-0222-y. Stem Cell Res Ther. 2015. PMID: 26651832 Free PMC article.

• Mechanobiology of mesenchymal stem cells: Which interest for cell-based treatment?

  Huselstein C, Rahouadj R, de Isla N, Bensoussan D, Stoltz JF, Li YP. Huselstein C, et al. Biomed Mater Eng. 2017;28(s1):S47-S56. doi: 10.3233/BME-171623. Biomed Mater Eng. 2017. PMID: 28372277 Review.

• Organ-specific migration of mesenchymal stromal cells: Who, when, where and why?

  Cornelissen AS, Maijenburg MW, Nolte MA, Voermans C. Cornelissen AS, et al. Immunol Lett. 2015 Dec;168(2):159-69. doi: 10.1016/j.imlet.2015.06.019. Epub 2015 Jul 14. Immunol Lett. 2015. PMID: 26187508 Review.

Cited by

• Liver Regeneration Following Thermal Ablation Using Nanocarrier Mediated Targeted Mesenchymal Stem Cell Therapy.

  Mohan PP, Deo S, Liu ZJ, Dikici E, Kaneku H, Chang D, Garcia-Buitrago M, Jalaeian H, Zeynaloo E, Ortiz YY, Li Y, Bhatia S, Velazquez O, Daunert S. Mohan PP, et al. Cardiovasc Intervent Radiol. 2025 Feb;48(2):233-243. doi: 10.1007/s00270-024-03862-2. Epub 2024 Nov 6. Cardiovasc Intervent Radiol. 2025. PMID: 39505737 Free PMC article.

• Rebuilding the myocardial microenvironment to enhance mesenchymal stem cells-mediated regeneration in ischemic heart disease.

  Chu Q, Jiang X, Xiao Y. Chu Q, et al. Front Bioeng Biotechnol. 2024 Sep 20;12:1468833. doi: 10.3389/fbioe.2024.1468833. eCollection 2024. Front Bioeng Biotechnol. 2024. PMID: 39372432 Free PMC article. Review.

• IL-1β mediated nanoscale surface clustering of integrin α5β1 regulates the adhesion of mesenchymal stem cells.

  Maynard SA, Pchelintseva E, Zwi-Dantsis L, Nagelkerke A, Gopal S, Korchev YE, Shevchuk A, Stevens MM. Maynard SA, et al. Sci Rep. 2021 Mar 25;11(1):6890. doi: 10.1038/s41598-021-86315-x. Sci Rep. 2021. PMID: 33767269 Free PMC article.

• Intravenously Infused Stem Cells for Cancer Treatment.

  Mercer-Smith AR, Findlay IA, Bomba HN, Hingtgen SD. Mercer-Smith AR, et al. Stem Cell Rev Rep. 2021 Dec;17(6):2025-2041. doi: 10.1007/s12015-021-10192-0. Epub 2021 Jun 17. Stem Cell Rev Rep. 2021. PMID: 34138421 Free PMC article. Review.

• Emerging role of mesenchymal stromal cells in gynecologic cancer therapy.

  Song Y, Liu H, Pan S, Xiang X, Ye M, Zhu X. Song Y, et al. Stem Cell Res Ther. 2023 Dec 5;14(1):347. doi: 10.1186/s13287-023-03585-0. Stem Cell Res Ther. 2023. PMID: 38049868 Free PMC article. Review.

Publication types

MeSH terms

LinkOut - more resources

• Full Text Sources

  • Ovid Technologies, Inc.
  • Silverchair Information Systems

• Other Literature Sources

  • The Lens - Patent Citations Database
  • scite Smart Citations