The Molecular and Morphologic Structures That Make Saltatory Conduction Possible in Peripheral Nerve - PubMed

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• PMID: 28340093
• DOI: 10.1093/jnen/nlx013

Review

The Molecular and Morphologic Structures That Make Saltatory Conduction Possible in Peripheral Nerve

Steven L Carroll. J Neuropathol Exp Neurol. 2017.

Abstract

Saltatory conduction is the process by which action potentials are rapidly and efficiently propagated along myelinated axons. In the peripheral nervous system, saltatory conduction is made possible by a series of morphologically and molecularly distinct subdomains in both axons and their associated myelinating Schwann cells. This review briefly summarizes current knowledge on the molecular structure and physiology of the node of Ranvier and adjacent regions of the axoglial unit in peripheral nerve.

Keywords: Axon; Ion channels; Node of Ranvier; Peripheral nerve; Saltatory conduction; Schwann cell.

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