Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes - PubMed

Affiliations

• PMID: 28346408
• DOI: 10.1038/ni.3713

Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes

Eliana Mariño et al. Nat Immunol. 2017 May.

Erratum in

• Erratum: Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes.

  Mariño E, Richards JL, McLeod KH, Stanley D, Yap YA, Knight J, McKenzie C, Kranich J, Oliveira AC, Rossello FJ, Krishnamurthy B, Nefzger CM, Macia L, Thorburn A, Baxter AG, Morahan G, Wong LH, Polo JM, Moore RJ, Lockett TJ, Clarke JM, Topping DL, Harrison LC, Mackay CR. Mariño E, et al. Nat Immunol. 2017 Jul 19;18(8):951. doi: 10.1038/ni0817-951c. Nat Immunol. 2017. PMID: 28722715 No abstract available.

• Erratum: Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes.

  Mariño E, Richards JL, McLeod KH, Stanley D, Yap YA, Knight J, McKenzie C, Kranich J, Oliveira AC, Rossello FJ, Krishnamurthy B, Nefzger CM, Macia L, Thorburn A, Baxter AG, Morahan G, Wong LH, Polo JM, Moore RJ, Lockett TJ, Clarke JM, Topping DL, Harrison LC, Mackay CR. Mariño E, et al. Nat Immunol. 2017 Oct 18;18(11):1271. doi: 10.1038/ni1117-1271c. Nat Immunol. 2017. PMID: 29044240

Abstract

Gut dysbiosis might underlie the pathogenesis of type 1 diabetes. In mice of the non-obese diabetic (NOD) strain, we found that key features of disease correlated inversely with blood and fecal concentrations of the microbial metabolites acetate and butyrate. We therefore fed NOD mice specialized diets designed to release large amounts of acetate or butyrate after bacterial fermentation in the colon. Each diet provided a high degree of protection from diabetes, even when administered after breakdown of immunotolerance. Feeding mice a combined acetate- and butyrate-yielding diet provided complete protection, which suggested that acetate and butyrate might operate through distinct mechanisms. Acetate markedly decreased the frequency of autoreactive T cells in lymphoid tissues, through effects on B cells and their ability to expand populations of autoreactive T cells. A diet containing butyrate boosted the number and function of regulatory T cells, whereas acetate- and butyrate-yielding diets enhanced gut integrity and decreased serum concentration of diabetogenic cytokines such as IL-21. Medicinal foods or metabolites might represent an effective and natural approach for countering the numerous immunological defects that contribute to T cell-dependent autoimmune diseases.

Comment in

• Dietary short-chain fatty acids protect against type 1 diabetes.

  Wen L, Wong FS. Wen L, et al. Nat Immunol. 2017 Apr 18;18(5):484-486. doi: 10.1038/ni.3730. Nat Immunol. 2017. PMID: 28418384 No abstract available.

• Microbiota: Diet can protect against type 1 diabetes.

  Kugelberg E. Kugelberg E. Nat Rev Immunol. 2017 May;17(5):279. doi: 10.1038/nri.2017.40. Epub 2017 Apr 19. Nat Rev Immunol. 2017. PMID: 28422177 No abstract available.

• Dietary therapy may be sufficient for type 1 diabetes treatment.

  Liu S, Chen X. Liu S, et al. Cell Mol Immunol. 2018 Feb;15(2):85-87. doi: 10.1038/cmi.2017.56. Epub 2017 Jul 10. Cell Mol Immunol. 2018. PMID: 28690325 Free PMC article. No abstract available.

• Diet as a strategy for type 1 diabetes prevention.

  Prodam F, Chiocchetti A, Dianzani U. Prodam F, et al. Cell Mol Immunol. 2018 Jan;15(1):1-4. doi: 10.1038/cmi.2017.54. Epub 2017 Jul 10. Cell Mol Immunol. 2018. PMID: 28690331 Free PMC article. No abstract available.

• Microbiota or short-chain fatty acids: which regulates diabetes?

  Kim CH. Kim CH. Cell Mol Immunol. 2018 Feb;15(2):88-91. doi: 10.1038/cmi.2017.57. Epub 2017 Jul 17. Cell Mol Immunol. 2018. PMID: 28713163 Free PMC article. No abstract available.

• Gut microbiota metabolites for sweetening type I diabetes.

  Aljutaily T, Consuegra-Fernández M, Aranda F, Lozano F, Huarte E. Aljutaily T, et al. Cell Mol Immunol. 2018 Feb;15(2):92-95. doi: 10.1038/cmi.2017.65. Epub 2017 Jul 31. Cell Mol Immunol. 2018. PMID: 28757611 Free PMC article. No abstract available.

• New therapeutic perspectives in Type 1 Diabetes: dietary interventions prevent β cell-autoimmunity by modifying the gut metabolic environment.

  Sorini C, Cosorich I, Falcone M. Sorini C, et al. Cell Mol Immunol. 2017 Dec;14(12):951-953. doi: 10.1038/cmi.2017.62. Epub 2017 Aug 7. Cell Mol Immunol. 2017. PMID: 28782754 Free PMC article. No abstract available.

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