Harnessing neural stem cells for treating psychiatric symptoms associated with fetal alcohol spectrum disorder and epilepsy - PubMed

Affiliations

• PMID: 28365374
• DOI: 10.1016/j.pnpbp.2017.03.021

Review

Harnessing neural stem cells for treating psychiatric symptoms associated with fetal alcohol spectrum disorder and epilepsy

Trenton Lippert et al. Prog Neuropsychopharmacol Biol Psychiatry. 2018.

Abstract

Brain insults with progressive neurodegeneration are inherent in pathological symptoms that represent many psychiatric illnesses. Neural network disruptions characterized by impaired neurogenesis have been recognized to precede, accompany, and possibly even exacerbate the evolution and progression of symptoms of psychiatric disorders. Here, we focus on the neurodegeneration and the resulting psychiatric symptoms observed in fetal alcohol spectrum disorder and epilepsy, in an effort to show that these two diseases are candidate targets for stem cell therapy. In particular, we provide preclinical evidence in the transplantation of neural stem cells (NSCs) in both conditions, highlighting the potential of this cell-based treatment for correcting the psychiatric symptoms that plague these two disorders. Additionally, we discuss the challenges of NSC transplantation and offer insights into the mechanisms that may mediate the therapeutic benefits and can be exploited to overcome the hurdles of translating this therapy from the laboratory to the clinic. Our ultimate goal is to advance stem cell therapy for the treatment of psychiatric disorders.

Keywords: Alcohol; Epilepsy; Fetal alcohol spectrum disorder; GABA; Neural stem cells; Neurodegeneration; Teratogenecity; Transplantation.

Similar articles

• Neural Stem Cells.

  Tuazon JP, Castelli V, Lee JY, Desideri GB, Stuppia L, Cimini AM, Borlongan CV. Tuazon JP, et al. Adv Exp Med Biol. 2019;1201:79-91. doi: 10.1007/978-3-030-31206-0_4. Adv Exp Med Biol. 2019. PMID: 31898782 Review.

• [Potential therapy of intravenous neural stem cell transplantation for psychiatric disorder--a strategy for facilitation of neural network and behavioral recovery].

  Shirasaka T, Kurosawa S. Shirasaka T, et al. Nihon Arukoru Yakubutsu Igakkai Zasshi. 2014 Oct;49(5):259-69. Nihon Arukoru Yakubutsu Igakkai Zasshi. 2014. PMID: 25651620 Japanese.

• The potential of neural stem cell transplantation for the treatment of fetal alcohol spectrum disorder.

  Poulos SG, Richie WD, Bailey RK, Lee A, Dela Peña I, Sanberg PR, Borlongan CV. Poulos SG, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2014 Oct 3;54:149-56. doi: 10.1016/j.pnpbp.2014.05.016. Epub 2014 Jun 2. Prog Neuropsychopharmacol Biol Psychiatry. 2014. PMID: 24943998 Review.

• [Promising therapy of neural stem cell transplantation for FASD model--neural network reconstruction and behavior recovery].

  Shirasaka T, Ukai W, Yoshinaga T, Watanabe K, Kaneta H, Kigawa Y, Igarashi T, Tateno M, Hashimoto E, Saito T. Shirasaka T, et al. Nihon Arukoru Yakubutsu Igakkai Zasshi. 2011 Dec;46(6):576-84. Nihon Arukoru Yakubutsu Igakkai Zasshi. 2011. PMID: 22413566 Japanese.

• Stem cell therapy: social recognition recovery in a FASD model.

  Shirasaka T, Hashimoto E, Ukai W, Yoshinaga T, Ishii T, Tateno M, Saito T. Shirasaka T, et al. Transl Psychiatry. 2012 Nov 13;2(11):e188. doi: 10.1038/tp.2012.111. Transl Psychiatry. 2012. PMID: 23149452 Free PMC article.

Cited by

• Humble beginnings with big goals: Small molecule soluble epoxide hydrolase inhibitors for treating CNS disorders.

  Zarriello S, Tuazon JP, Corey S, Schimmel S, Rajani M, Gorsky A, Incontri D, Hammock BD, Borlongan CV. Zarriello S, et al. Prog Neurobiol. 2019 Jan;172:23-39. doi: 10.1016/j.pneurobio.2018.11.001. Epub 2018 Nov 14. Prog Neurobiol. 2019. PMID: 30447256 Free PMC article. Review.

• Stem cells and mechanisms regulating their trafficking - a new and challenging area of investigation in modern psychiatry.

  Ratajczak MZ. Ratajczak MZ. Prog Neuropsychopharmacol Biol Psychiatry. 2018 Jan 3;80(Pt A):1-2. doi: 10.1016/j.pnpbp.2017.08.018. Prog Neuropsychopharmacol Biol Psychiatry. 2018. PMID: 28962830 Free PMC article. No abstract available.

• Hippocampal Neural Stem Cell Grafting after Status Epilepticus Alleviates Chronic Epilepsy and Abnormal Plasticity, and Maintains Better Memory and Mood Function.

  Hattiangady B, Kuruba R, Shuai B, Grier R, Shetty AK. Hattiangady B, et al. Aging Dis. 2020 Dec 1;11(6):1374-1394. doi: 10.14336/AD.2020.1020. eCollection 2020 Dec. Aging Dis. 2020. PMID: 33269095 Free PMC article.

• Understanding Intra- and Inter-Species Variability in Neural Stem Cells' Biology Is Key to Their Successful Cryopreservation, Culture, and Propagation.

  Radoszkiewicz K, Jezierska-Woźniak K, Waśniewski T, Sarnowska A. Radoszkiewicz K, et al. Cells. 2023 Feb 2;12(3):488. doi: 10.3390/cells12030488. Cells. 2023. PMID: 36766833 Free PMC article.

Publication types

MeSH terms

LinkOut - more resources

• Full Text Sources

  • Elsevier Science
  • Ovid Technologies, Inc.

• Other Literature Sources

  • scite Smart Citations

• Medical

  • MedlinePlus Consumer Health Information
  • MedlinePlus Health Information