Necropsy findings in rhesus monkeys experimentally infected with cultured simian immunodeficiency virus (SIV)/delta - PubMed

Necropsy findings in rhesus monkeys experimentally infected with cultured simian immunodeficiency virus (SIV)/delta

G B Baskin et al. Vet Pathol. 1988 Nov.

Abstract

Lesions induced in rhesus monkeys by different isolates of simian immunodeficiency virus (SIV)/Delta were studied at necropsy. Four groups of monkeys were inoculated with SIV/Delta isolated from other experimentally infected rhesus monkeys, while one group was inoculated with SIV/Delta from an asymptomatic mangabey monkey. Three rhesus isolates and the mangabey isolate were virulent, killing 75-100% of infected monkeys. One rhesus isolate, which had been extensively passaged in vitro, was attenuated but was restored to virulence by single animal passage. Clinically, infected monkeys had lymphadenopathy, splenomegaly, diarrhea, and a rash. Most monkeys died of enteric disease. The following lesions were seen: weight loss, thymic atrophy, lymphoid atrophy, bone marrow hyperplasia, encephalitis, colitis, amyloidosis, hepatitis, glomerulosclerosis, and the presence of syncytial cells. One Rh Epstein-Barr virus (EBV)-related lymphoma occurred. Opportunistic agents were identified: cytomegalovirus, adenovirus, Cryptosporidia, and Pneumocystis. Shigella and Campylobacter often caused colitis.

Similar articles

• Experimental infection of rhesus monkeys with SIV isolated from African green monkeys.

  Herchenröder O, Stahl-Hennig C, Lüke W, Schneider J, Schulze G, Hartmann H, Schmidt H, Tenner-Racz K, Racz P, Hayami M, et al. Herchenröder O, et al. Intervirology. 1989;30 Suppl 1:66-72. doi: 10.1159/000150126. Intervirology. 1989. PMID: 2540114

• Comparative biology of natural and experimental SIVmac infection in macaque monkeys: a review.

  King NW, Chalifoux LV, Ringler DJ, Wyand MS, Sehgal PK, Daniel MD, Letvin NL, Desrosiers RC, Blake BJ, Hunt RD. King NW, et al. J Med Primatol. 1990;19(2):109-18. J Med Primatol. 1990. PMID: 2160016

• Pathology of dual Mycobacterium leprae and simian immunodeficiency virus infection in rhesus monkeys.

  Baskin GB, Gormus BJ, Martin LN, Murphey-Corb M, Walsh GP, Meyers WM. Baskin GB, et al. Int J Lepr Other Mycobact Dis. 1990 Jun;58(2):358-64. Int J Lepr Other Mycobact Dis. 1990. PMID: 2165511

• [The immunological manifestations and cytological characteristics of infection caused by the simian immunodeficiency virus (SIV) in rhesus monkeys].

  Persidskiĭ IuV, Shcherbinskaia AM, Barshteĭn IuA, Antonenko SV, Marichev IL. Persidskiĭ IuV, et al. Tsitol Genet. 1993 Nov-Dec;27(6):97-104. Tsitol Genet. 1993. PMID: 8066812 Review. Russian.

• Nonhuman primate retrovirus isolates and AIDS.

  Gardner MB, Luciw P, Lerche N, Marx P. Gardner MB, et al. Adv Vet Sci Comp Med. 1988;32:171-226. doi: 10.1016/b978-0-12-039232-2.50011-6. Adv Vet Sci Comp Med. 1988. PMID: 2903617 Review. No abstract available.

Cited by

• Feline leukemia virus infection as a potentiating cofactor for the primary and secondary stages of experimentally induced feline immunodeficiency virus infection.

  Pedersen NC, Torten M, Rideout B, Sparger E, Tonachini T, Luciw PA, Ackley C, Levy N, Yamamoto J. Pedersen NC, et al. J Virol. 1990 Feb;64(2):598-606. doi: 10.1128/JVI.64.2.598-606.1990. J Virol. 1990. PMID: 2153226 Free PMC article.

• Direct relationship between suppression of virus-specific immunity and emergence of cytomegalovirus disease in simian AIDS.

  Kaur A, Kassis N, Hale CL, Simon M, Elliott M, Gomez-Yafal A, Lifson JD, Desrosiers RC, Wang F, Barry P, Mach M, Johnson RP. Kaur A, et al. J Virol. 2003 May;77(10):5749-58. doi: 10.1128/jvi.77.10.5749-5758.2003. J Virol. 2003. PMID: 12719568 Free PMC article.

• Unique pathology in simian immunodeficiency virus-infected rapid progressor macaques is consistent with a pathogenesis distinct from that of classical AIDS.

  Brown CR, Czapiga M, Kabat J, Dang Q, Ourmanov I, Nishimura Y, Martin MA, Hirsch VM. Brown CR, et al. J Virol. 2007 Jun;81(11):5594-606. doi: 10.1128/JVI.00202-07. Epub 2007 Mar 21. J Virol. 2007. PMID: 17376901 Free PMC article.

• Wide range of viral load in healthy african green monkeys naturally infected with simian immunodeficiency virus.

  Goldstein S, Ourmanov I, Brown CR, Beer BE, Elkins WR, Plishka R, Buckler-White A, Hirsch VM. Goldstein S, et al. J Virol. 2000 Dec;74(24):11744-53. doi: 10.1128/jvi.74.24.11744-11753.2000. J Virol. 2000. PMID: 11090174 Free PMC article.

• Genetic variation at the mitochondrial large-subunit rRNA locus of Pneumocystis isolates from simian immunodeficiency virus-infected rhesus macaques.

  Norris KA, Wildschutte H, Franko J, Board KF. Norris KA, et al. Clin Diagn Lab Immunol. 2003 Nov;10(6):1037-42. doi: 10.1128/cdli.10.6.1037-1042.2003. Clin Diagn Lab Immunol. 2003. PMID: 14607864 Free PMC article.

Publication types

MeSH terms

LinkOut - more resources

• Full Text Sources

  • Atypon