Prevalence of chromosomal aberrations in Argentinean agricultural workers - PubMed

Affiliations

• PMID: 28730367
• DOI: 10.1007/s11356-017-9664-3

Prevalence of chromosomal aberrations in Argentinean agricultural workers

Graciela Eugenia Bianco et al. Environ Sci Pollut Res Int. 2017 Sep.

Abstract

Little is known about biosecurity measures and toxic effects during pesticide application in the province of Jujuy, Argentina, particularly concerning the protective measures and mixture of pesticides used by rural workers. We carried out an observational study of agricultural workers from Jujuy (76 exposed subjects and 53 controls) to investigate the prevalence of chromosomal aberrations (CAs) in human lymphocytes as well as the activity level of acetylcholinesterase (AChE) in red blood cell erythrocytes. Whole blood samples (5 mL) were collected in heparinized Vacutainer tubes for cytogenetic analysis and erythrocyte cholinesterase activity determination according to Ellman's method. Cytogenetic results showed a significant CA increase in pesticide-exposed individuals as compared with controls (4.20 ± 0.15 vs. 1.00 ± 0.05, respectively; p < 0.001), suggesting that pesticides are clastogenic agents causing DNA damage. Erythrocyte cholinesterase activity was significantly lower in exposed individuals, evidencing the possible occurrence of perturbations in blood as well as neurotoxicity in pesticide sprayers. These results suggest the need for periodic biomonitoring of these biomarkers together with education and training of occupational workers for the safe application of potentially harmful pesticides.

Keywords: Chromosome aberrations; Dicentric chromosomes, acetylcholinesterase activity; Erythrocyte cholinesterase activity; Lymphocyte cultures; Pesticides.

Similar articles

• Determination of AChE levels and genotoxic effects in farmers occupationally exposed to pesticides.

  Naravaneni R, Jamil K. Naravaneni R, et al. Hum Exp Toxicol. 2007 Sep;26(9):723-31. doi: 10.1177/0960327107083450. Hum Exp Toxicol. 2007. PMID: 17984143

• Evaluation of genetic damage in pesticides applicators from the province of Córdoba, Argentina.

  Aiassa DE, Mañas FJ, Gentile NE, Bosch B, Salinero MC, Gorla NBM. Aiassa DE, et al. Environ Sci Pollut Res Int. 2019 Jul;26(20):20981-20988. doi: 10.1007/s11356-019-05344-2. Epub 2019 May 21. Environ Sci Pollut Res Int. 2019. PMID: 31115805

• [Biochemical evaluation on rural workers exposed to pesticides].

  Simoniello MF, Kleinsorge EC, Carballo MA. Simoniello MF, et al. Medicina (B Aires). 2010;70(6):489-98. Medicina (B Aires). 2010. PMID: 21163734 Spanish.

• Pesticides, chromosomal aberrations, and non-Hodgkin's lymphoma.

  Chiu BC, Blair A. Chiu BC, et al. J Agromedicine. 2009;14(2):250-5. doi: 10.1080/10599240902773140. J Agromedicine. 2009. PMID: 19437285 Free PMC article. Review.

• Cancer among pesticide manufacturers and applicators.

  Burns CJ. Burns CJ. Scand J Work Environ Health. 2005;31 Suppl 1:9-17; discussion 5-7. Scand J Work Environ Health. 2005. PMID: 16190144 Review.

Cited by

• Health Effects of Pesticide Exposure in Latin American and the Caribbean Populations: A Scoping Review.

  Zúñiga-Venegas LA, Hyland C, Muñoz-Quezada MT, Quirós-Alcalá L, Butinof M, Buralli R, Cardenas A, Fernandez RA, Foerster C, Gouveia N, Gutiérrez Jara JP, Lucero BA, Muñoz MP, Ramírez-Santana M, Smith AR, Tirado N, van Wendel de Joode B, Calaf GM, Handal AJ, Soares da Silva A, Cortés S, Mora AM. Zúñiga-Venegas LA, et al. Environ Health Perspect. 2022 Sep;130(9):96002. doi: 10.1289/EHP9934. Epub 2022 Sep 29. Environ Health Perspect. 2022. PMID: 36173136 Free PMC article.

References

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Springer

• Other Literature Sources

  • scite Smart Citations

• Medical

  • MedlinePlus Health Information