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Genetic analysis of impulsive personality traits: Examination of a priori candidates and genome-wide variation - PubMed

Genetic analysis of impulsive personality traits: Examination of a priori candidates and genome-wide variation

Joshua C Gray et al. Psychiatry Res. 2018 Jan.

Abstract

Impulsive personality traits are heritable risk factors and putative endophenotypes for addiction and other psychiatric disorders involving disinhibition. This study examined the genetic basis of impulsive personality traits, defined as scores on the Barratt Impulsiveness Scale (BIS-11) and the UPPS-P Impulsive Behavior Scale (UPPS-P). In 983 healthy young adults of European ancestry, the study examined genetic variation in relation to a combined phenotype of seven subscales based on high phenotypic intercorrelations. The study first tested 14 a priori loci that have previously been associated impulsive personality traits or closely related constructs. Second, the study included an exploratory genome-wide scan (i.e., GWAS), acknowledging that only relatively large effects would be detectable in a sample size of ~ 1000. A priori SNP analyses revealed a significant association between the combined impulsivity phenotype and two SNPs within the 5-HT2a receptor gene (HTR2A; rs6313 and rs6311). Follow-up analyses suggested that the effects were specific to the Motor and Non-planning subscales on the BIS-11, and also that the two loci were in linkage disequilibrium. The GWAS yielded no statistically significant findings. This study further implicates loci within HTR2A with certain forms of self-reported impulsivity and identifies candidates for future investigation from the genome-wide analyses.

Keywords: Endophenotype; Genetics; Impulsivity; Personality traits; Serotonin.

Published by Elsevier B.V.

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Conflict of interest statement

Conflict of interest

The authors do not have any actual or potential conflict of interest to disclose.

Figures

Figure 1
Figure 1

Manhattan plot of genome-wide association for impulsive personality traits multivariate regression models with adjustment for sex, age, and site. Significance values were – log10 transformed in order to display the smaller p-values as larger in the figure. The Manhattan plot displays level of significance for each SNP, organized by chromosomal position from chromosomes 1–22. The blue line indicates suggestive significance (10−5). No SNPs achieve genome-wide significance (p < 5 × 10−8).

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