The Role of Succinate in Regulation of Immediate HIF-1α Expression in Hypoxia - PubMed

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• PMID: 29308570
• DOI: 10.1007/s10517-018-3976-2

The Role of Succinate in Regulation of Immediate HIF-1α Expression in Hypoxia

L D Lukyanova et al. Bull Exp Biol Med. 2018 Jan.

Abstract

Hypoxia-induced immediate expression of transcription factor HIF-1α in the brain cortex is regulated by succinate produced in both the tricarbonic acid cycle and GABA shunt reactions and is induced by succinate-containing drugs. These facts prove the existence of succinate-dependent signalling regulation involved in immediate and delayed molecular adaptation and increased body resistance to oxygen deficiency, where succinate acts as a signal molecule. The intensity of this process differs in animals with low and high resistance to hypoxia.

Keywords: GABA shunt; HIF-1α; hypoxia; succinate.

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