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Comparative study of interhemispheric functional connectivity in left eye monocular blindness versus right eye monocular blindness: a resting-state functional MRI study - PubMed

  • ️Mon Jan 01 2018

Comparative study of interhemispheric functional connectivity in left eye monocular blindness versus right eye monocular blindness: a resting-state functional MRI study

Yi Shao et al. Oncotarget. 2018.

Abstract

Objective: In the present study, we investigated the brain interhemispheric functional connectivity changes in left eye MB versus right eye MB patients by voxel-mirrored homotopic connectivity (VMHC) methods.

Methods: A total of 31 patients with MB (15 with left eye MB and 16 with right eye MB), and 31 healthy controls (HCs) closely matched for age were recruited. All subjects underwent functional magnetic resonance imaging (fMRI) examinations. The VMHC method was used to evaluate directly functional interactions between the hemispheres. A one-way ANOVA was performed to determine the regions in which the VMHC differs between the three groups. Patients with MB were distinguished from HCs by a receiver operating characteristic (ROC) curve. The relationships between the mean VMHC signal values in many brain regions and clinical features in MB patients were calculated by pearson correlation analysis.

Results: Compared with HCs, MB patients had significantly decreased VMHC values in the cuneus/calcarine/lingual gyrus. Furthermore, left eye MB showed decreased VMHC values in the cuneus/calcarine/lingual gyrus and showed increased VMHC values in the insula and middle frontal gyrus compared with HC. In addition, right eye MB showed decreased VMHC values in the cuneus/calcarine/lingual gyrus, primary motor cortex (M1)/primary somatosensory cortex (S1) and superior parietal lobule.

Conclusion: MB subjects showed abnormal brain interhemispheric functional connectivity in visual pathways. Furthermore, different patterns of brain interhemispheric functional connectivity occurred in the left eye and right eye MB. These VMHC values provide much useful information to explain the neural mechanism changes in MB.

Keywords: functional magnetic resonance imaging; monocular blindness; resting state; voxel-mirrored homotopic connectivity.

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Conflict of interest statement

CONFLICTS OF INTEREST None.

Figures

Figure 1
Figure 1. One sample t-test results

Within-group VMHC maps within the MB (left) and HC (right) (A), Left MB (left) and HC (right) (B), right MB (left) and HC (right) (C) (p < 0.001, FDR corrected). Abbreviations: VMHC, voxel-mirrored homotopic connectivity; MB, monocular blindness; HC, healthy controls; FDR, false discovery rate.

Figure 2
Figure 2. Interhemispheric functional connectivity in the MBs and HCs

Significant activity differences were observed in the cuneus/calcarine/lingual gyrus, the blue areas indicate lower VMHC values, respectively (P < 0.01 for multiple comparisons using Gaussian Random Field (GRF) theory (z > 2.3, P < 0.01, cluster > 20 voxels, FDR corrected). (A) and (B) The mean values of altered VMHC values between the MBs and HCs groups. (C) Abbreviations: VMHC, voxel-mirrored homotopic connectivity; MB, monocular blindness; HC, healthy controls; Cun, cuneus; Cal, calcarine; Lgg, lingual gyrus.

Figure 3
Figure 3. Interhemispheric functional connectivity in the left eye MBs and HCs

Significant activity differences were observed in the cuneus/calcarine/lingual gyrus, insula and middle frontal gyrus. The red or yellow denotes higher VMHC values, and the blue areas indicate lower VMHC values, respectively (P < 0.01 for multiple comparisons using Gaussian Random Field (GRF) theory (z > 2.3, P < 0.01, cluster >20 voxels, FDR corrected). (A) and (B) The mean values of altered VMHC values between the left eye MBs and HCs groups. (C) Abbreviations: VMHC, voxel-mirrored homotopic connectivity; MB, monocular blindness; HC, healthy controls; Cun, cuneus; Cal, calcarine; Lgg, lingual gyrus; MFG, middle frontal gyrus.

Figure 4
Figure 4. Interhemispheric functional connectivity in the right eye MBs and HCs

Significant activity differences were observed in the cuneus/calcarine/lingual gyrus, primary motor cortex (M1)/primary somatosensory cortex (S1) and superior parietal lobule, the blue areas indicate lower VMHC values, respectively (P < 0.01 for multiple comparisons using Gaussian Random Field (GRF) theory (z > 2.3, P < 0.01, cluster >20 voxels, FDR corrected). (A) and (B) The mean values of altered VMHC values between the right eye MBs and HCs groups. (C) Abbreviations: VMHC, voxel-mirrored homotopic connectivity; MB, monocular blindness; HC, healthy controls; Cun, cuneus; Cal, calcarine; Lgg, lingual gyrus; M1, primary motor cortex; S1, primary somatosensory cortex; SPL, superior parietal lobule.

Figure 5
Figure 5. ROC curve analysis of the mean VMHC values for altered brain regions

Notes: (A) ROC curve: MB < HC, for the Cun/Cal/Lgg 0.845 (p < 0.001; 95% CI: 0.746–0.944); (B) ROC curve: LMB < HC for the Cun/Cal/Lgg 0.895(p < 0.001; 95% CI: 0.772–1.000); (C) ROC curve: LMB > HC for the Insula 0.910 (p < 0.001; 95% CI: 0.808–1.000) and MFG 0.843 (p = 0.002; 95% CI: 0.700–0.986) ; (D) ROC curve: RMB < HC for the Cun/Cal/Lgg, 0.827 (p = 0.001; 95% CI: 0.671–0.983) and M1/S1 0.813(p = 0.002; 95% CI: 0.658–0.967) and SPL 0.831 (p = 0.001; 95% CI: 0.688–0.974; Abbreviations: VMHC, voxel-mirrored homotopic connectivity; ROC, receiver operating characteristic; ReHo, regional homogeneity; CI, confidence interval; MB, monocular blindness; HC, healthy control; Cun, cuneus; Cal, calcarine; Lgg, lingual gyrus; M1, primary motor cortex; S1, primary somatosensory cortex; SPL, superior parietal lobule.

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