Adenosine signaling and the immune system: When a lot could be too much - PubMed

Review

Adenosine signaling and the immune system: When a lot could be too much

Luca Antonioli et al. Immunol Lett. 2019 Jan.

Abstract

Adenosine is increasingly recognized as a key mediator of the immune response. Signals delivered by extracellular adenosine are detected and transduced by G-protein-coupled cell-surface receptors, classified into four subtypes: A₁, A_2A, A_2B and A₃. These receptors, expressed virtually on all immune cells, modulate all aspects of immune/inflammatory responses. These immunoregulatory effects, which are mostly anti-inflammatory, contribute to the general tissue protective effects of adenosine and its receptors. In some instances, however, the effect of adenosine on the immune system is deleterious, as prolonged adenosine signaling can hinder anti-tumor and antibacterial immunity, thereby promoting cancer development and progression and sepsis, respectively.

Keywords: Adenosine; Adenosine receptors; Cancer; Immune cells; Inflammation.

Similar articles

• Adenosine and adenosine receptors in the pathogenesis and treatment of rheumatic diseases.

  Cronstein BN, Sitkovsky M. Cronstein BN, et al. Nat Rev Rheumatol. 2017 Jan;13(1):41-51. doi: 10.1038/nrrheum.2016.178. Epub 2016 Nov 10. Nat Rev Rheumatol. 2017. PMID: 27829671 Free PMC article. Review.

• Modulation of innate immunity by adenosine receptor stimulation.

  Ramakers BP, Riksen NP, van der Hoeven JG, Smits P, Pickkers P. Ramakers BP, et al. Shock. 2011 Sep;36(3):208-15. doi: 10.1097/SHK.0b013e318225aee4. Shock. 2011. PMID: 21617576 Review.

• Immunological alterations mediated by adenosine during host-microbial interactions.

  Drygiannakis I, Ernst PB, Lowe D, Glomski IJ. Drygiannakis I, et al. Immunol Res. 2011 May;50(1):69-77. doi: 10.1007/s12026-011-8207-0. Immunol Res. 2011. PMID: 21479929 Free PMC article. Review.

• Adenosine metabolism, immunity and joint health.

  Haskó G, Antonioli L, Cronstein BN. Haskó G, et al. Biochem Pharmacol. 2018 May;151:307-313. doi: 10.1016/j.bcp.2018.02.002. Epub 2018 Feb 7. Biochem Pharmacol. 2018. PMID: 29427624 Free PMC article. Review.

• The Adenosine System at the Crossroads of Intestinal Inflammation and Neoplasia.

  D'Antongiovanni V, Fornai M, Pellegrini C, Benvenuti L, Blandizzi C, Antonioli L. D'Antongiovanni V, et al. Int J Mol Sci. 2020 Jul 18;21(14):5089. doi: 10.3390/ijms21145089. Int J Mol Sci. 2020. PMID: 32708507 Free PMC article. Review.

Cited by

• Unlocking antitumor immunity with adenosine receptor blockers.

  Remley VA, Linden J, Bauer TW, Dimastromatteo J. Remley VA, et al. Cancer Drug Resist. 2023 Oct 25;6(4):748-767. doi: 10.20517/cdr.2023.63. eCollection 2023. Cancer Drug Resist. 2023. PMID: 38263981 Free PMC article. Review.

• Exploring the Effect of Halogenation in a Series of Potent and Selective A_2B Adenosine Receptor Antagonists.

  Prieto-Díaz R, González-Gómez M, Fojo-Carballo H, Azuaje J, El Maatougui A, Majellaro M, Loza MI, Brea J, Fernández-Dueñas V, Paleo MR, Díaz-Holguín A, Garcia-Pinel B, Mallo-Abreu A, Estévez JC, Andújar-Arias A, García-Mera X, Gomez-Tourino I, Ciruela F, Salas CO, Gutiérrez-de-Terán H, Sotelo E. Prieto-Díaz R, et al. J Med Chem. 2023 Jan 12;66(1):890-912. doi: 10.1021/acs.jmedchem.2c01768. Epub 2022 Dec 14. J Med Chem. 2023. PMID: 36517209 Free PMC article.

• Exploring Differential Transcriptome between Jejunal and Cecal Tissue of Broiler Chickens.

  Bertocchi M, Sirri F, Palumbo O, Luise D, Maiorano G, Bosi P, Trevisi P. Bertocchi M, et al. Animals (Basel). 2019 May 7;9(5):221. doi: 10.3390/ani9050221. Animals (Basel). 2019. PMID: 31067716 Free PMC article.

• Adenosine Receptor Reserve and Long-Term Potentiation: Unconventional Adaptive Mechanisms in Cardiovascular Diseases?

  Guieu R, Brignole M, Deharo JC, Deharo P, Mottola G, Groppelli A, Paganelli F, Ruf J. Guieu R, et al. Int J Mol Sci. 2021 Jul 15;22(14):7584. doi: 10.3390/ijms22147584. Int J Mol Sci. 2021. PMID: 34299203 Free PMC article. Review.

• Diabetes and hypertension: Pivotal involvement of purinergic signaling.

  Reichert KP, Castro MFV, Assmann CE, Bottari NB, Miron VV, Cardoso A, Stefanello N, Morsch VMM, Schetinger MRC. Reichert KP, et al. Biomed Pharmacother. 2021 May;137:111273. doi: 10.1016/j.biopha.2021.111273. Epub 2021 Jan 30. Biomed Pharmacother. 2021. PMID: 33524787 Free PMC article. Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • ClinicalKey
  • Elsevier Science

• Other Literature Sources

  • scite Smart Citations