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The Clinical Use of Stem Cell Research in Chronic Obstructive Pulmonary Disease: A Critical Analysis of Current Policies - PubMed

Review

. 2018 Sep;10(9):671-678.

doi: 10.14740/jocmr3484w. Epub 2018 Jul 31.

Affiliations

PMID: 30116436
PMCID: PMC6089575
DOI: 10.14740/jocmr3484w

Review

The Clinical Use of Stem Cell Research in Chronic Obstructive Pulmonary Disease: A Critical Analysis of Current Policies

Domenico Maurizio Toraldo et al. J Clin Med Res. 2018 Sep.

Abstract

Chronic obstructive pulmonary disease (COPD) is a disorder affecting more than 200 million people around the world, resulting in three million deaths per year. COPD is characterized by the loss of lung tissue and airway remodelling, with chronic inflammation of the airways and progressive destruction of lung parenchyma. The use of stem cells may lead to regenerative processes that address biological damage. However, this approach raises ethical issues that need to be considered in clinical trials using stem cell therapy, such as informed consent, patient recruitment and harm minimization, as well as the inherent uncertainty of these medical procedures on human beings. Indeed, up to now, these experiments have been performed in preclinical studies using animal models, with few studies involving humans. Additional efforts should be made to assess this promising procedure.

Keywords: Chronic obstructive pulmonary disease; Induced pluripotent stem cells.

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Conflict of interest statement

The authors declare that they do not have a conflict of interest.

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