Is mitochondrial gene expression coordinated or stochastic? - PubMed

Affiliations

• PMID: 30301847
• DOI: 10.1042/BST20180174

Review

Is mitochondrial gene expression coordinated or stochastic?

Richard G Lee et al. Biochem Soc Trans. 2018.

Abstract

Mitochondrial biogenesis is intimately dependent on the coordinated expression of the nuclear and mitochondrial genomes that is necessary for the assembly and function of the respiratory complexes to produce most of the energy required by cells. Although highly compacted in animals, the mitochondrial genome and its expression are essential for survival, development, and optimal energy production. The machinery that regulates gene expression within mitochondria is localised within the same compartment and, like in their ancestors, the bacteria, this machinery does not use membrane-based compartmentalisation to order the gene expression pathway. Therefore, the lifecycle of mitochondrial RNAs from transcription through processing, maturation, translation to turnover is mediated by a gamut of RNA-binding proteins (RBPs), all contained within the mitochondrial matrix milieu. Recent discoveries indicate that multiple processes regulating RNA metabolism occur at once but since mitochondria have a new complement of RBPs, many evolved de novo from nuclear genes, we are left wondering how co-ordinated are these processes? Here, we review recently identified examples of the co-ordinated and stochastic processes that govern the mitochondrial transcriptome. These new discoveries reveal the complexity of mitochondrial gene expression and the need for its in-depth exploration to understand how these organelles can respond to the energy demands of the cell.

Keywords: RNA metabolism; RNA-binding proteins; protein synthesis.

Similar articles

• Posttranscriptional control of mitochondrial biogenesis: spatio-temporal regulation of the protein import process.

  Devaux F, Lelandais G, Garcia M, Goussard S, Jacq C. Devaux F, et al. FEBS Lett. 2010 Oct 22;584(20):4273-9. doi: 10.1016/j.febslet.2010.09.030. Epub 2010 Sep 26. FEBS Lett. 2010. PMID: 20875412 Review.

• The role of mammalian PPR domain proteins in the regulation of mitochondrial gene expression.

  Rackham O, Filipovska A. Rackham O, et al. Biochim Biophys Acta. 2012 Sep-Oct;1819(9-10):1008-16. doi: 10.1016/j.bbagrm.2011.10.007. Epub 2011 Oct 26. Biochim Biophys Acta. 2012. PMID: 22051507

• The human mitochondrial transcriptome and the RNA-binding proteins that regulate its expression.

  Rackham O, Mercer TR, Filipovska A. Rackham O, et al. Wiley Interdiscip Rev RNA. 2012 Sep-Oct;3(5):675-95. doi: 10.1002/wrna.1128. Epub 2012 Jul 9. Wiley Interdiscip Rev RNA. 2012. PMID: 22777840 Review.

• Synchronized mitochondrial and cytosolic translation programs.

  Couvillion MT, Soto IC, Shipkovenska G, Churchman LS. Couvillion MT, et al. Nature. 2016 May 26;533(7604):499-503. doi: 10.1038/nature18015. Epub 2016 May 11. Nature. 2016. PMID: 27225121 Free PMC article.

• A concert of RNA-binding proteins coordinates mitochondrial function.

  Schatton D, Rugarli EI. Schatton D, et al. Crit Rev Biochem Mol Biol. 2018 Dec;53(6):652-666. doi: 10.1080/10409238.2018.1553927. Crit Rev Biochem Mol Biol. 2018. PMID: 30741581 Review.

Cited by

• MitoRibo-Tag Mice Provide a Tool for In Vivo Studies of Mitoribosome Composition.

  Busch JD, Cipullo M, Atanassov I, Bratic A, Silva Ramos E, Schöndorf T, Li X, Pearce SF, Milenkovic D, Rorbach J, Larsson NG. Busch JD, et al. Cell Rep. 2019 Nov 5;29(6):1728-1738.e9. doi: 10.1016/j.celrep.2019.09.080. Cell Rep. 2019. PMID: 31693908 Free PMC article.

• Fidelity of translation initiation is required for coordinated respiratory complex assembly.

  Rudler DL, Hughes LA, Perks KL, Richman TR, Kuznetsova I, Ermer JA, Abudulai LN, Shearwood AJ, Viola HM, Hool LC, Siira SJ, Rackham O, Filipovska A. Rudler DL, et al. Sci Adv. 2019 Dec 20;5(12):eaay2118. doi: 10.1126/sciadv.aay2118. eCollection 2019 Dec. Sci Adv. 2019. PMID: 31903419 Free PMC article.

• Mitochondrial Protection by PARP Inhibition.

  Gallyas F Jr, Sumegi B. Gallyas F Jr, et al. Int J Mol Sci. 2020 Apr 16;21(8):2767. doi: 10.3390/ijms21082767. Int J Mol Sci. 2020. PMID: 32316192 Free PMC article. Review.

• Mitochondrial Gene Expression and Beyond-Novel Aspects of Cellular Physiology.

  Kotrys AV, Szczesny RJ. Kotrys AV, et al. Cells. 2019 Dec 19;9(1):17. doi: 10.3390/cells9010017. Cells. 2019. PMID: 31861673 Free PMC article. Review.

• Organization and expression of the mammalian mitochondrial genome.

  Rackham O, Filipovska A. Rackham O, et al. Nat Rev Genet. 2022 Oct;23(10):606-623. doi: 10.1038/s41576-022-00480-x. Epub 2022 Apr 22. Nat Rev Genet. 2022. PMID: 35459860 Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Silverchair Information Systems