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Sleep duration and 24-hour ambulatory blood pressure in adults not on antihypertensive medications - PubMed

Comparative Study

. 2018 Dec;20(12):1712-1720.

doi: 10.1111/jch.13416. Epub 2018 Oct 30.

Affiliations

Comparative Study

Sleep duration and 24-hour ambulatory blood pressure in adults not on antihypertensive medications

Rachel Shulman et al. J Clin Hypertens (Greenwich). 2018 Dec.

Abstract

Short sleep duration has been widely linked to increased cardiovascular morbidity and mortality. We performed a post hoc analysis of 24-hour ambulatory blood pressure monitoring (ABPM) in the Lifestyle Modification in Blood Pressure Lowering Study (LIMBS) and Penn Icelandic Sleep Apnea (PISA) Study. The 24-hour mean systolic blood pressure (BP) was 12.7 mm Hg higher in LIMBS (P < 0.001; n = 66) and 4.7 mm Hg higher in PISA (P = 0.005; n = 153) among participants with shorter sleep duration (less than 7 hours) compared to those with longer sleep duration (at least 7 hours). In multivariable adjusted models, shorter sleep duration was strongly associated with higher systolic BP on 24-hour ABPM, independent of nocturnal BP and in-office BP. There was no effect modification by obstructive sleep apnea. Adults with shorter sleep duration may benefit from screening with 24-hour ABPM to promote earlier detection of hypertension and potentially mitigate their increased risk for future cardiovascular disease.

Keywords: ambulatory; blood pressure monitoring; circadian rhythm; hypertension; obstructive sleep apnea; sleep deprivation; sleep disorders.

©2018 Wiley Periodicals, Inc.

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Conflict of interest statement

The authors of this manuscript declare no relevant conflicts of interest.

Figures

Figure 1
Figure 1

Mean 24‐h systolic blood pressure (SBP) in (A) LIMBS and (B) PISA. The graphs represent mean 24‐h SBP (bars) and 95% confidence intervals (capped lines) during the full 24‐h period, self‐reported wake time (“Daytime”), and self‐reported sleep time (“Nocturnal”). Mean SBP was stratified by sleep duration. Shorter sleep duration was defined as <7 h; longer sleep duration was defined as ≥7 h. *Indicative of a statistically significant difference (P < 0.05) between the shorter and longer sleep duration groups

Figure 2
Figure 2

Adjusted 24‐h systolic blood pressure (SBP) and sleep duration in (A) LIMBS and (B) PISA. The graphs represent the linear association (solid lines) and 95% confidence intervals (shading) of the multivariable models evaluating the association between mean 24‐h SBP and sleep duration, adjusted for age, race, and BMI

Comment in

  • Sleep and blood pressure.

    Lattanzi S, Brigo F, Silvestrini M. Lattanzi S, et al. J Clin Hypertens (Greenwich). 2018 Dec;20(12):1721-1723. doi: 10.1111/jch.13423. Epub 2018 Oct 30. J Clin Hypertens (Greenwich). 2018. PMID: 30375713 Free PMC article. No abstract available.

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