Age-related diseases as vicious cycles - PubMed

Review

Age-related diseases as vicious cycles

Aleksey V Belikov. Ageing Res Rev. 2019 Jan.

Abstract

The mortality rates of age-related diseases (ARDs) increase exponentially with age. Processes described by the exponential growth function typically involve a branching chain reaction or, more generally, a positive feedback loop. Here I propose that each ARD is mediated by one or several positive feedback loops (vicious cycles). I then identify critical vicious cycles in five major ARDs: atherosclerosis, hypertension, diabetes, Alzheimer's and Parkinson's. I also propose that the progression of ARDs can be halted by selectively interrupting the vicious cycles and suggest the most promising targets.

Keywords: Aging; Alzheimer’s; Atherosclerosis; Diabetes; Hypertension; Parkinson’s.

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