The Roles of Different Stem Cells in Premature Ovarian Failure - PubMed

Review

The Roles of Different Stem Cells in Premature Ovarian Failure

Cheng Zhang. Curr Stem Cell Res Ther. 2020.

Abstract

Premature ovarian failure (POF) is characterized by amenorrhea, hypergonadotropism and hypoestrogenism before the age of 40, which affects 1% of women in the general population. POF is complex and heterogeneous due to its pathogenetic mechanisms. It is one of the significant causes of female infertility. Although many treatments are available for POF, these therapies are less efficient and trigger many side effects. Therefore, to find effective therapeutics for POF is urgently required. Due to stem cells having self-renewal and regeneration potential, they may be effective for the treatment of ovarian failure and consequently infertility. Recent studies have found that stem cells therapy may be able to restore the ovarian structure and function in animal models of POF and provide an effective treatment method. The present review summarizes the biological roles and the possible signaling mechanisms of the different stem cells in POF ovary. Further study on the precise mechanisms of stem cells on POF may provide novel insights into the female reproduction, which not only enhances the understanding of the physiological roles but also supports effective therapy for recovering ovarian functions against infertility.

Keywords: Premature ovarian failure; amenorrhea; gonadotropin; hypergonadotropism; hypoestrogenism; ovary; stem cells.

Similar articles

• Current approaches for the treatment of premature ovarian failure with stem cell therapy.

  Sheikhansari G, Aghebati-Maleki L, Nouri M, Jadidi-Niaragh F, Yousefi M. Sheikhansari G, et al. Biomed Pharmacother. 2018 Jun;102:254-262. doi: 10.1016/j.biopha.2018.03.056. Epub 2018 Mar 22. Biomed Pharmacother. 2018. PMID: 29567538 Review.

• Stem cell-based therapeutic potential in female ovarian aging and infertility.

  Cui X, Jing X. Cui X, et al. J Ovarian Res. 2024 Aug 24;17(1):171. doi: 10.1186/s13048-024-01492-3. J Ovarian Res. 2024. PMID: 39182123 Free PMC article. Review.

• Tracking of human embryonic stem cell-derived mesenchymal stem cells in premature ovarian failure model mice.

  Bahrehbar K, Khanjarpoor Malakhond M, Gholami S. Bahrehbar K, et al. Biochem Biophys Res Commun. 2021 Nov 5;577:6-11. doi: 10.1016/j.bbrc.2021.08.063. Epub 2021 Aug 26. Biochem Biophys Res Commun. 2021. PMID: 34487961

• The Therapeutic Effect of Stem Cells on Chemotherapy-Induced Premature Ovarian Failure.

  Chen H, Liu C, Zhu S, Li S, Zhang Q, Song L, Liang X. Chen H, et al. Curr Mol Med. 2021;21(5):376-384. doi: 10.2174/1566524020666200905113907. Curr Mol Med. 2021. PMID: 32888266 Free PMC article. Review.

• Embryonic stem cells-derived mesenchymal stem cells do not differentiate into ovarian cells but improve ovarian function in POF mice.

  Bahrehbar K, Gholami S, Nazari Z, Malakhond MK. Bahrehbar K, et al. Biochem Biophys Res Commun. 2022 Dec 20;635:92-98. doi: 10.1016/j.bbrc.2022.10.014. Epub 2022 Oct 9. Biochem Biophys Res Commun. 2022. PMID: 36265287

Cited by

• Exosomes as Biomarkers for Female Reproductive Diseases Diagnosis and Therapy.

  Esfandyari S, Elkafas H, Chugh RM, Park HS, Navarro A, Al-Hendy A. Esfandyari S, et al. Int J Mol Sci. 2021 Feb 22;22(4):2165. doi: 10.3390/ijms22042165. Int J Mol Sci. 2021. PMID: 33671587 Free PMC article. Review.

• Female germline stem cells: aging and anti-aging.

  Hong W, Wang B, Zhu Y, Wu J, Qiu L, Ling S, Zhou Z, Dai Y, Zhong Z, Zheng Y. Hong W, et al. J Ovarian Res. 2022 Jul 4;15(1):79. doi: 10.1186/s13048-022-01011-2. J Ovarian Res. 2022. PMID: 35787298 Free PMC article. Review.

• Human Mesenchymal Stem Cell Therapy and Other Novel Treatment Approaches for Premature Ovarian Insufficiency.

  Ulin M, Cetin E, Hobeika E, Chugh RM, Park HS, Esfandyari S, Al-Hendy A. Ulin M, et al. Reprod Sci. 2021 Jun;28(6):1688-1696. doi: 10.1007/s43032-021-00528-z. Epub 2021 May 6. Reprod Sci. 2021. PMID: 33956339 Free PMC article. Review.

• Mesenchymal stem cells to treat female infertility; future perspective and challenges: A review.

  Saeed Y, Liu X. Saeed Y, et al. Int J Reprod Biomed. 2022 Oct 10;20(9):709-722. doi: 10.18502/ijrm.v20i9.12061. eCollection 2022 Sep. Int J Reprod Biomed. 2022. PMID: 36340664 Free PMC article. Review.

• Mesenchymal Stem Cells in Preclinical Infertility Cytotherapy: A Retrospective Review.

  Chang Z, Zhu H, Zhou X, Zhang Y, Jiang B, Li S, Chen L, Pan X, Feng XL. Chang Z, et al. Stem Cells Int. 2021 May 17;2021:8882368. doi: 10.1155/2021/8882368. eCollection 2021. Stem Cells Int. 2021. PMID: 34054970 Free PMC article. Review.

Publication types

MeSH terms

LinkOut - more resources

• Full Text Sources

  • Bentham Science Publishers Ltd.
  • Ingenta plc

• Medical

  • MedlinePlus Health Information