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From R.A. Fisher's 1918 Paper to GWAS a Century Later - PubMed

From R.A. Fisher's 1918 Paper to GWAS a Century Later

Peter M Visscher et al. Genetics. 2019 Apr.

Abstract

The genetics and evolution of complex traits, including quantitative traits and disease, have been hotly debated ever since Darwin. A century ago, a paper from R.A. Fisher reconciled Mendelian and biometrical genetics in a landmark contribution that is now accepted as the main foundation stone of the field of quantitative genetics. Here, we give our perspective on Fisher's 1918 paper in the context of how and why it is relevant in today's genome era. We mostly focus on human trait variation, in part because Fisher did so too, but the conclusions are general and extend to other natural populations, and to populations undergoing artificial selection.

Keywords: Fisher 1918; GWAS; quantitative trait.

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References

1. Bloom J. S., Kotenko I., Sadhu M. J., Treusch S., Albert F. W., et al. , 2015. Genetic interactions contribute less than additive effects to quantitative trait variation in yeast. Nat. Commun. 6: 8712 10.1038/ncomms9712 - DOI - PMC - PubMed
1. Charlesworth B., Edwards A. W. F., 2018. A century of variance. Significance 15: 20–25.
1. Edwards J. H., 1969. Familial predisposition in man. Br. Med. Bull. 25: 58–64. 10.1093/oxfordjournals.bmb.a070672 - DOI - PubMed
1. Falconer D., 1965. The inheritance of liability to certain diseases, estimates from the incidence among relatives. Ann. Hum. Genet. 29: 51–76. 10.1111/j.1469-1809.1965.tb00500.x - DOI
1. Falconer D. S., Mackay T. F. C., 1996. Introduction to Quantitative Genetics. Longman, Harlow, Essex.

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From R.A. Fisher's 1918 Paper to GWAS a Century Later - PubMed