pubmed.ncbi.nlm.nih.gov

Non-secretion of ABO blood group antigens as a host susceptibility factor in the spondyloarthropathies - PubMed

️Thu Jan 01 1987

Non-secretion of ABO blood group antigens as a host susceptibility factor in the spondyloarthropathies

R Shinebaum et al. Br Med J (Clin Res Ed). 1987.

Abstract

Gram negative bacteria precipitate reactive arthritis and may be concerned in the pathogenesis of ankylosing spondylitis and other spondyloarthropathies. Susceptibility to many infectious agents is associated with ABO blood group or secretor state, or both. The distribution of the ABO blood group or secretor state, or both, was therefore determined in 87 patients with ankylosing spondylitis and 32 with other forms of spondyloarthropathy. The prevalence of non-secretors was significantly increased in the total patient group (54/114; 47%) and in the subgroup with ankylosing spondylitis (41/84; 49%) compared with local controls (89/334; 27%) (p less than 0.001). Other subgroups of patients showed a similarly increased prevalence of non-secretion (33-47%). The distribution of ABO blood groups did not differ between patients and controls. The association between non-secretor state and ankylosing spondylitis strengthens the hypothesis that ankylosing spondylitis is a form of reactive arthritis. It also suggests several pathogenic mechanisms which may be relevant to the initial hostparasite interaction in ankylosing spondylitis.

PubMed Disclaimer

Cited by

Pseudomonas colonization in cystic fibrosis: lack of correlation with secretion of ABO blood group antigens.
Mulherin D, Coffey MJ, Keogan MJ, O'Brien P, FitzGerald MX. Mulherin D, et al. Ir J Med Sci. 1990 Jul;159(7):217-8. doi: 10.1007/BF02937270. Ir J Med Sci. 1990. PMID: 2126537
Calculating confidence intervals for relative risks (odds ratios) and standardised ratios and rates.
Morris JA, Gardner MJ. Morris JA, et al. Br Med J (Clin Res Ed). 1988 May 7;296(6632):1313-6. doi: 10.1136/bmj.296.6632.1313. Br Med J (Clin Res Ed). 1988. PMID: 3133061 Free PMC article. No abstract available.
AB0 and Lewis blood groups in reactive arthritis.
Tertti R, Järvinen H, Lahesmaa R, Yli-Kerttula U, Toivanen A. Tertti R, et al. Rheumatol Int. 1992;12(3):103-5. doi: 10.1007/BF00290263. Rheumatol Int. 1992. PMID: 1411088
Immunoglobulin allotype Gm(1,2;21) in ankylosing spondylitis with peripheral arthritis.
Mierau R, von Mühlen CA, Zarnowski H, Genth E, Hartl PW. Mierau R, et al. Ann Rheum Dis. 1988 Nov;47(11):893-7. doi: 10.1136/ard.47.11.893. Ann Rheum Dis. 1988. PMID: 3264692 Free PMC article.
Association between secretor status and respiratory viral illness.
Raza MW, Blackwell CC, Molyneaux P, James VS, Ogilvie MM, Inglis JM, Weir DM. Raza MW, et al. BMJ. 1991 Oct 5;303(6806):815-8. doi: 10.1136/bmj.303.6806.815. BMJ. 1991. PMID: 1932971 Free PMC article.

References

1. Ann Rheum Dis. 1973 Nov;32(6):493-6 - PubMed
1. Ann Rheum Dis. 1980 Apr;39(2):118-23 - PubMed
1. Rheumatol Rehabil. 1977 Aug;16(3):190-6 - PubMed
1. Arthritis Rheum. 1976 Jul-Aug;19(4):656-68 - PubMed
1. Arthritis Rheum. 1981 Jun;24(6):844-9 - PubMed

Non-secretion of ABO blood group antigens as a host susceptibility factor in the spondyloarthropathies - PubMed