Ultradian oscillations of plasma glucose, insulin, and C-peptide in man during continuous enteral nutrition - PubMed

Ultradian oscillations of plasma glucose, insulin, and C-peptide in man during continuous enteral nutrition

C Simon et al. J Clin Endocrinol Metab. 1987 Apr.

Abstract

The profiles of plasma glucose, insulin, and C-peptide were studied in normal men receiving continuous enteral nutrition. Large oscillations occurred with periods of 53-113 min. Their mean amplitudes, expressed as a percentage of the 24-h mean, were as high as 20% for glucose, 54% for insulin, and 56% for C-peptide. The oscillations of plasma insulin levels throughout the 24 h were concomitant with those of C-peptide. Rapid 8- to 14-min plasma insulin and glucose oscillations were smaller in magnitude and could only be detected in some segments of the longer period oscillations. These results indicate that in addition to the previously described 8- to 14-min oscillations, plasma glucose, insulin, and C-peptide oscillate at a mean 80-min periodicity in man during continuous enteral nutrition. These oscillations may reflect a pancreatic oscillatory mechanism and/or cyclic variations in gastrointestinal motility or peripheral glucose uptake.

Similar articles

• Slow oscillations of plasma glucose and insulin secretion rate are amplified during sleep in humans under continuous enteral nutrition.

  Simon C, Brandenberger G, Saini J, Ehrhart J, Follenius M. Simon C, et al. Sleep. 1994 Jun;17(4):333-8. doi: 10.1093/sleep/17.4.333. Sleep. 1994. PMID: 7973317 Clinical Trial.

• L-arginine: an ultradian-regulated substrate coupled with insulin oscillations in healthy volunteers.

  Schaefer A, Simon C, Viola AU, Piquard F, Geny B, Brandenberger G. Schaefer A, et al. Diabetes Care. 2003 Jan;26(1):168-71. doi: 10.2337/diacare.26.1.168. Diabetes Care. 2003. PMID: 12502675

• Alteration in the temporal organisation of insulin secretion in type 2 (non-insulin-dependent) diabetic patients under continuous enteral nutrition.

  Simon C, Brandenberger G, Follenius M, Schlienger JL. Simon C, et al. Diabetologia. 1991 Jun;34(6):435-40. doi: 10.1007/BF00403183. Diabetologia. 1991. PMID: 1909248

• Computer model for mechanisms underlying ultradian oscillations of insulin and glucose.

  Sturis J, Polonsky KS, Mosekilde E, Van Cauter E. Sturis J, et al. Am J Physiol. 1991 May;260(5 Pt 1):E801-9. doi: 10.1152/ajpendo.1991.260.5.E801. Am J Physiol. 1991. PMID: 2035636 Review.

• On high-frequency insulin oscillations.

  Schmitz O, Rungby J, Edge L, Juhl CB. Schmitz O, et al. Ageing Res Rev. 2008 Dec;7(4):301-5. doi: 10.1016/j.arr.2008.04.002. Epub 2008 May 3. Ageing Res Rev. 2008. PMID: 18583199 Review.

Cited by

• "Smart" continuous glucose monitoring sensors: on-line signal processing issues.

  Sparacino G, Facchinetti A, Cobelli C. Sparacino G, et al. Sensors (Basel). 2010;10(7):6751-72. doi: 10.3390/s100706751. Epub 2010 Jul 12. Sensors (Basel). 2010. PMID: 22163574 Free PMC article. Review.

• Pulsatility of insulin and glucagon release: physiological significance and pharmacological implications.

  Lefèbvre PJ, Paolisso G, Scheen AJ, Henquin JC. Lefèbvre PJ, et al. Diabetologia. 1987 Jul;30(7):443-52. doi: 10.1007/BF00279610. Diabetologia. 1987. PMID: 3311858 Review. No abstract available.

• Postprandial oscillations of plasma glucose, insulin and C-peptide in man.

  Simon C, Follenius M, Brandenberger G. Simon C, et al. Diabetologia. 1987 Oct;30(10):769-73. doi: 10.1007/BF00275742. Diabetologia. 1987. PMID: 3322902

• Multi-Timescale Rhythmicity of Blood Glucose and Insulin Delivery Reveals Key Advantages of Hybrid Closed Loop Therapy.

  Grant AD, Lewis DM, Kriegsfeld LJ. Grant AD, et al. J Diabetes Sci Technol. 2022 Jul;16(4):912-920. doi: 10.1177/1932296821994825. Epub 2021 Mar 10. J Diabetes Sci Technol. 2022. PMID: 33719596 Free PMC article.

• Modulation of glucose regulation and insulin secretion by circadian rhythmicity and sleep.

  Van Cauter E, Blackman JD, Roland D, Spire JP, Refetoff S, Polonsky KS. Van Cauter E, et al. J Clin Invest. 1991 Sep;88(3):934-42. doi: 10.1172/JCI115396. J Clin Invest. 1991. PMID: 1885778 Free PMC article.

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Silverchair Information Systems

• Medical

  • MedlinePlus Health Information