An Examination of the Development and Localization of Key Immune Cells in Developing Pouch Young of the Red-Tailed Phascogale (Phascogale calura) - PubMed
. 2019 Nov;302(11):1985-2002.
doi: 10.1002/ar.24176. Epub 2019 Jun 10.
Affiliations
- PMID: 31120185
- DOI: 10.1002/ar.24176
Free article
An Examination of the Development and Localization of Key Immune Cells in Developing Pouch Young of the Red-Tailed Phascogale (Phascogale calura)
Casey R Borthwick et al. Anat Rec (Hoboken). 2019 Nov.
Free article
Abstract
Cells expressing the surface markers CD3, CD4, CD79b, IgM, MHC class II, and ModoUG (nonclassical MHC class I) were detected in red-tailed phascogale tissues using immunohistochemistry, and the appearance and localization of cells observed here was consistent with previous observations in other marsupial species. CD3+ cells were first detected at one day postpartum (dpp) in the thymus, followed by ModoUG+ cells at 5-7 dpp in the thymus and lymph nodes. CD79b+ cells were first detected at 12-14 dpp in bone marrow, spleen, and lymph nodes. IgM+ cells were first detected at 12-14 dpp in thymus, bone marrow, spleen, and lymph nodes. MHC class II+ cells were first detected at 12-14 dpp in thymus, bone marrow, and lymph nodes. CD4+ cells were detected in adult thymus and spleen only. The presence of the mature immune cell populations and their localization to characteristic T and B cell zones in mature lymphoid tissues with normal histological structure indicates that red-tailed phascogales develop immunocompetence by the end of pouch life. Anat Rec, 302:1985-2002, 2019. © 2019 American Association for Anatomy.
Keywords: B cell; MHC; T cell; dasyurid; immune tissue; marsupial.
© 2019 American Association for Anatomy.
Similar articles
-
Borthwick CR, Old JM. Borthwick CR, et al. Anat Rec (Hoboken). 2016 Feb;299(2):207-19. doi: 10.1002/ar.23297. Epub 2015 Dec 18. Anat Rec (Hoboken). 2016. PMID: 26599205
-
Old JM, Selwood L, Deane EM. Old JM, et al. J Anat. 2004 Jul;205(1):25-33. doi: 10.1111/j.0021-8782.2004.00310.x. J Anat. 2004. PMID: 15255959 Free PMC article.
-
Borthwick CR, Young LJ, Old JM. Borthwick CR, et al. Mol Immunol. 2018 Sep;101:268-275. doi: 10.1016/j.molimm.2018.07.005. Epub 2018 Jul 18. Mol Immunol. 2018. PMID: 30029061
-
The development of the immune tissues in marsupial pouch young.
Borthwick CR, Young LJ, Old JM. Borthwick CR, et al. J Morphol. 2014 Jul;275(7):822-39. doi: 10.1002/jmor.20250. Epub 2014 Jan 28. J Morphol. 2014. PMID: 24469962 Review.
-
Red-tailed phascogales: A review of their biology and importance as model marsupial species.
Old JM, Ong OTW, Stannard HJ. Old JM, et al. J Exp Zool A Ecol Integr Physiol. 2021 Feb;335(2):217-227. doi: 10.1002/jez.2438. Epub 2020 Dec 31. J Exp Zool A Ecol Integr Physiol. 2021. PMID: 33382214 Review.
References
Literature Cited
-
- Ahn S, Cunningham-Rundles C. 2009. Role of B cells in common variable immune deficiency. Expert Rev Clin Immu 5:557-564.
-
- Alexandropoulos K, Danzl NM. 2012. Thymic epithelial cells: antigen presenting cells that regulate T cell repertoire and tolerance development. Immunol Res 54:177-190.
-
- Andersen MH, Schrama D, thor Straten P, Becker JC. 2006. Cytotoxic T cells. J Investig Dermatol 126(1):32-41.
-
- von Andrian UH, Mempel TR. 2003. Homing and cellular traffic in lymph nodes. Nat Rev Immunol 3:867-878.
-
- Baker ML, Gemmell E, Gemmell RT. 1999. Ontogeny of the immune system of the brushtail possum, Trichosurus vulpecula. Anat Rec 256:354-365.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Research Materials