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Language impairment in primary progressive aphasia and other neurodegenerative diseases - PubMed

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Language impairment in primary progressive aphasia and other neurodegenerative diseases

D R Rahul et al. J Genet. 2019 Nov.

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Abstract

Primary progressive aphasia (PPA) is a progressive neurodegenerative disease that disrupts the language capacity of an individual by selectively affecting the language network of brain. Although aphasic literature is replete with reports of brain damage responsible for various types of PPA, it does not provide a comprehensive understanding of whether PPA is an independent pathological condition or an atypical syndrome of neurodegenerative diseases (NDD). To address this ambiguity, we provide a detailed description of PPA, its variants and their brain anatomy. Subsequently, we unravel the relationship between PPA and NDDs like Alzheimer's, Parkinson's and Dyslexia. To substantiate the relationship further, we also provide a brief account of their genetic aetiology. In the final section, we offer an exhaustive approach towards the treatment of PPA by combining the existing language the rapies with clinical and pharmacological interventions.

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References

    1. Neuropsychologia. 2017 Jul 1;101:132-140 - PubMed
    1. J Genet. 2018 Dec;97(5):1485-1491 - PubMed
    1. Neuron. 2011 Oct 20;72(2):257-68 - PubMed
    1. Am J Hum Genet. 2011 Jul 15;89(1):162-7 - PubMed
    1. Brain Lang. 2005 Apr;93(1):55-63 - PubMed

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