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Protocol of the SOMNIA project: an observational study to create a neurophysiological database for advanced clinical sleep monitoring - PubMed

️Tue Jan 01 2019

. 2019 Nov 25;9(11):e030996.

doi: 10.1136/bmjopen-2019-030996.

Johannes P van Dijk^{3

2}, Roy Krijn^{3

2}, Bertram Hoondert^{3

2}, Pedro Fonseca^{3

4}, Ruud J G van Sloun³, Bruno Arsenali³, Nele Vandenbussche^{3

2}, Sigrid Pillen^{2

5}, Henning Maass⁴, Leonie van den Heuvel⁴, Reinder Haakma⁴, Tim R Leufkens^{4

5}, Coen Lauwerijssen⁶, Jan W M Bergmans^{3

4}, Dirk Pevernagie², Sebastiaan Overeem^{3

2}

Affiliations

PMID: 31772091
PMCID: PMC6886950
DOI: 10.1136/bmjopen-2019-030996

Protocol of the SOMNIA project: an observational study to create a neurophysiological database for advanced clinical sleep monitoring

Merel M van Gilst et al. BMJ Open. 2019.

Abstract

Introduction: Polysomnography (PSG) is the primary tool for sleep monitoring and the diagnosis of sleep disorders. Recent advances in signal analysis make it possible to reveal more information from this rich data source. Furthermore, many innovative sleep monitoring techniques are being developed that are less obtrusive, easier to use over long time periods and in the home situation. Here, we describe the methods of the Sleep and Obstructive Sleep Apnoea Monitoring with Non-Invasive Applications (SOMNIA) project, yielding a database combining clinical PSG with advanced unobtrusive sleep monitoring modalities in a large cohort of patients with various sleep disorders. The SOMNIA database will facilitate the validation and assessment of the diagnostic value of the new techniques, as well as the development of additional indices and biomarkers derived from new and/or traditional sleep monitoring methods.

Methods and analysis: We aim to include at least 2100 subjects (both adults and children) with a variety of sleep disorders who undergo a PSG as part of standard clinical care in a dedicated sleep centre. Full-video PSG will be performed according to the standards of the American Academy of Sleep Medicine. Each recording will be supplemented with one or more new monitoring systems, including wrist-worn photoplethysmography and actigraphy, pressure sensing mattresses, multimicrophone recording of respiratory sounds including snoring, suprasternal pressure monitoring and multielectrode electromyography of the diaphragm.

Ethics and dissemination: The study was reviewed by the medical ethical committee of the Maxima Medical Center (Eindhoven, the Netherlands, File no: N16.074). All subjects provide informed consent before participation.The SOMNIA database is built to facilitate future research in sleep medicine. Data from the completed SOMNIA database will be made available for collaboration with researchers outside the institute.

Keywords: database; neurophysiology; polysomnography; sleep medicine.

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Conflict of interest statement

Competing interests: PF, TL, HM, RH, JWMB and LvdH are employees of Philips Research. CL is employee of 2M Engineering.

Figures

**Figure 1**
Placement of the body-worn experimental sensors. Light grey circle: suprasternal pressure monitoring; Dark gray circle: diaphragm EMG; Dark square: wrist-worn photoplethysmography. EMG, electromyogram.

**Figure 2**
Microphone set-up at the top end of the bed. (A) Two microphones for high fidelity recordings (Earthworks M23) are placed at different heights at the midline of the bed. (B) Two microphones for average quality recordings (Behringer ECM8000) are placed at the same height at the sides of the bed and one on the night stand.

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