[Maurice Raynaud (1834-1881) and the Mystery of "Raynaud's Phanomenon"] - PubMed

[Article in German]

• PMID: 31847013
• DOI: 10.1055/a-0869-9899

[Maurice Raynaud (1834-1881) and the Mystery of "Raynaud's Phanomenon"]

[Article in German]

Ulrich Koehler et al. Dtsch Med Wochenschr. 2019 Dec.

Abstract

Maurice Raynaud first described color changes and symptoms of the fingers due to cold-induced vasospasm and restricted blood flow in his medical school thesis in 1862. Raynaud's phenomenon is common and exists as an uncomplicated primary Raynaud phenomenon and a Raynaud phenomenon secondary to underlying diseases and medication. Mechanisms contributing to altered vasoconstrictor activity are endothelial and not-endothelial. Cold-induced vasospasm is probably a thermoregulatory problem and effects are mediated by sympathetic activity and selective stimulation of alpha_2c-adrenoreceptors.

Conflict of interest statement

Die Autoren geben an, dass kein Interessenkonflikt besteht.

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