Knockout Mouse Models for Peroxiredoxins - PubMed
- ️Wed Jan 01 2020
Review
Knockout Mouse Models for Peroxiredoxins
Young Jae Lee. Antioxidants (Basel). 2020.
Abstract
Peroxiredoxins (PRDXs) are members of a highly conserved peroxidase family and maintain intracellular reactive oxygen species (ROS) homeostasis. The family members are expressed in most organisms and involved in various biological processes, such as cellular protection against ROS, inflammation, carcinogenesis, atherosclerosis, heart diseases, and metabolism. In mammals, six PRDX members have been identified and are subdivided into three subfamilies: typical 2-Cys (PRDX1, PRDX2, PRDX3, and PRDX4), atypical 2-Cys (PRDX5), and 1-Cys (PRDX6) subfamilies. Knockout mouse models of PRDXs have been developed to investigate their in vivo roles. This review presents an overview of the knockout mouse models of PRDXs with emphases on the biological and physiological changes of these model mice.
Keywords: animal model; knockout mouse; peroxides; peroxiredoxin; reactive oxygen species.
Conflict of interest statement
The author declares no conflict of interest.
Figures
Catalytic cycle of typical 2-Cys (a), atypical 2-Cys (b), and 1-Cys (c) peroxiredoxins (PRDXs). CP, peroxidatic cysteine; CR, resolving cysteine; GSH, glutathione; ROOH, peroxide; Trx, thioredoxin.
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