Clinical features, prognostic factors and outcome in a series of 29 extra-skeletal Ewing Sarcoma. Adequate margins and surgery-radiotherapy association improve overall survival - PubMed
- ️Wed Jan 01 2020
. 2020 Mar 25:21:236-239.
doi: 10.1016/j.jor.2020.03.018. eCollection 2020 Sep-Oct.
Nicola Mondanelli 2 , Lorenzo Pelagatti 1 , Filippo Frenos 1 , Davide Matera 1 , Giovanni Beltrami 1 , Matteo Innocenti 1 , Rodolfo Capanna 3 , Giuliana Roselli 4 , Guido Scoccianti 1 , Lorenzo Livi 5 , Daniela Greto 5 , Cristina Muntoni 5 , Giacomo Baldi 6 , Angela Tamburini 7 , Domenico Andrea Campanacci 1
Affiliations
- PMID: 32273664
- PMCID: PMC7132112
- DOI: 10.1016/j.jor.2020.03.018
Clinical features, prognostic factors and outcome in a series of 29 extra-skeletal Ewing Sarcoma. Adequate margins and surgery-radiotherapy association improve overall survival
Francesco Muratori et al. J Orthop. 2020.
Abstract
Objective: Authors review a series of 29 extra-skeletal Ewing Sarcoma (EES).
Methods: They analyzed characteristics, prognostic factors and outcome of EES.
Results: Authors report 60% Overall Survival (OS) and 56% of Event Free Survival (EFS) at 5 years. Better 5 years EFS was found in patients with localized disease (68.8%) compared to metastatic EES (33.3%) (p = 0.042). Radiotherapy + surgery offered the best local treatment (p=0.017). Volume (p = 0.032), Surgical margins (p = 0.01), metastatic disease (p = 0.0013) were a significant prognostic factor for OS at 5-yrs.
Conclusion: Adequate margins and surgery+radiotherapy improve Overall Survival.
Keywords: Ewing sarcoma; Extra-skeletal; Margins; Metastasis; Surgery; Volume.
© 2020 Professor P K Surendran Memorial Education Foundation. Published by Elsevier B.V. All rights reserved.
Conflict of interest statement
The authors report no conflict of interest concerning the materials or methods used in this study or the findings specified in this paper.
Figures
5-yrs Overall Survival in extra-skeletal Ewing Sarcoma.
5-yrs Evidence Free Survival in extra-skeletal Ewing Sarcoma.
5-yrs Evidence Free Survival in metastastic EES and not.
5-yrs Overall Survival in metastastic EES and not.
5-yrs Overall Survival based on the treatment.
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