pubmed.ncbi.nlm.nih.gov

Averting transmission: A pivotal target to manage amoebiasis - PubMed

Review

. 2020 Aug;96(2):731-744.

doi: 10.1111/cbdd.13699. Epub 2020 May 25.

Affiliations

Review

Averting transmission: A pivotal target to manage amoebiasis

Aadish Rawat et al. Chem Biol Drug Des. 2020 Aug.

Abstract

Amoebiasis is a parasitic infectious disease caused by the enteric protozoan Entamoeba histolytica, a leading basis of deaths accounted to parasites, succeeding malaria and schistosomiasis. Conventional treatment methodologies used to deal with amoebiasis mainly rely on the administration of anti-amoebic compounds and vaccines but are often linked with substantial side-effects on the patient. Besides, cases of development of drug resistance in protozoans have been recorded, contributing further to the reduction in the efficiency of the treatment. Loopholes in the efficacious management of the disease call for the development of novel methodologies to manage amoebiasis. A way to achieve this is by targeting the essential metabolic processes of 'encystation' and 'excystation', and the associated biomolecules, thus interrupting the biphasic life cycle of the parasite. Technologies like the CRISPR-Cas9 system can efficiently be exploited to discover novel and essential molecules that regulate the protozoan's metabolism, while efficiently manipulating and managing the known drug targets, leading to an effective halt and forestall to the enteric infection. This review presents a perspective on these essential metabolic processes and the associated molecules that can be targeted efficaciously to prevent the transmission of amoebiasis, thus managing the disease and proving to be a fruitful endeavour.

Keywords: Entamoeba histolytica; amoebiasis; cyst; encystation; excystation; parasitic infections; trophozoites.

© 2020 John Wiley & Sons A/S.

PubMed Disclaimer

Similar articles

Cited by

References

REFERENCES

    1. Aguilar-Díaz, H., Carrero, J. C., Argüello-García, R., Laclette, J. P., & Morales-Montor, J. (2011). Cyst and encystment in protozoan parasites: Optimal targets for new life-cycle interrupting strategies? Trends in Parasitology, 27(10), 450-458. https://doi.org/10.1016/j.pt.2011.06.003
    1. Al-Areeqi, M. A., Sady, H., Al-Mekhlafi, H. M., Anuar, T. S., Al-Adhroey, A. H., Atroosh, W. M., … Surin, J. (2017). First molecular epidemiology of Entamoeba histolytica, E. dispar and E. moshkovskii infections in Yemen: Different species-specific associated risk factors. Tropical Medicine & International Health, 22(4), 493-504. https://doi.org/10.1111/tmi.12848
    1. Ali, I. K. M., Haque, R., Siddique, A., Kabir, M., Sherman, N. E., Gray, S. A., … Petri, W. A. (2012). Proteomic analysis of the cyst stage of Entamoeba histolytica. PLoS Neglected Tropical Diseases, 6(5), e1643. https://doi.org/10.1371/journal.pntd.0001643
    1. Ang, C. W., Jarrad, A. M., Cooper, M. A., & Blaskovich, M. A. T. (2017). Nitroimidazoles: Molecular fireworks that combat a broad spectrum of infectious diseases. Journal of Medicinal Chemistry, 60(18), 7636-7657. https://doi.org/10.1021/acs.jmedchem.7b00143
    1. Ankri, S., Padilla-Vaca, F., Stolarsky, T., Koole, L., Katz, U., & Mirelman, D. (1999). Antisense inhibition of expression of the light subunit (35 kDa) of the Gal/GalNac lectin complex inhibits Entamoeba histolytica virulence. Molecular Microbiology, 33(2), 327-337. https://doi.org/10.1046/j.1365-2958.1999.01476.x

Publication types

MeSH terms

Substances

LinkOut - more resources