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Muscle-Organ Crosstalk: The Emerging Roles of Myokines - PubMed

  • ️Wed Jan 01 2020

Review

Muscle-Organ Crosstalk: The Emerging Roles of Myokines

Mai Charlotte Krogh Severinsen et al. Endocr Rev. 2020.

Erratum in

Abstract

Physical activity decreases the risk of a network of diseases, and exercise may be prescribed as medicine for lifestyle-related disorders such as type 2 diabetes, dementia, cardiovascular diseases, and cancer. During the past couple of decades, it has been apparent that skeletal muscle works as an endocrine organ, which can produce and secrete hundreds of myokines that exert their effects in either autocrine, paracrine, or endocrine manners. Recent advances show that skeletal muscle produces myokines in response to exercise, which allow for crosstalk between the muscle and other organs, including brain, adipose tissue, bone, liver, gut, pancreas, vascular bed, and skin, as well as communication within the muscle itself. Although only few myokines have been allocated to a specific function in humans, it has been identified that the biological roles of myokines include effects on, for example, cognition, lipid and glucose metabolism, browning of white fat, bone formation, endothelial cell function, hypertrophy, skin structure, and tumor growth. This suggests that myokines may be useful biomarkers for monitoring exercise prescription for people with, for example, cancer, diabetes, or neurodegenerative diseases.

Keywords: cancer; cytokines; diabetes; exercise; metabolism; physical activity.

© Endocrine Society 2020.

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Figures

Graphical Abstract
Graphical Abstract
Figure 1.
Figure 1.

Musclin, LIF, IL-4, IL-6, IL-7, and IL-15 promote muscle hypertrophy. Myostatin inhibits muscle hypertrophy.

Figure 2.
Figure 2.

Cathepsin B and irisin cross the blood–brain barrier and stimulate BDNF production, which leads to hippocampal neurogenesis. IL-6 stimulates appetite. Abbreviations: BDNF, brain-derived neurotrophic factor.

Figure 3.
Figure 3.

IL-6 stimulates lipolysis decreases visceral fat mass. Irisin, meteorin-like, and IL-6 have a role in “browning” of white adipose tissue. IL-6 and BDNF stimulate AMPK activation. Abbreviations: AMPK, 5′-AMP-activated protein kinase; BDNF, brain-derived neurotrophic factor.

Figure 4.
Figure 4.

Decorin, IL-6, IGF-1, and FGF-2 positively regulate bone formation. Abbreviations: FGF-2, fibroblast growth factor 2; IGF-1, insulin-like growth factor I.

Figure 5.
Figure 5.

Angiogenin, osteoprotegerin, and IL-6 possess pancreatic β-cell protective actions against proinflammatory cytokines. IL-6 increases insulin secretion by inducing the expression of GLP-1 by the L cells of the intestine. Abbreviations: GLP-1, glucagon-like peptide 1.

Figure 6.
Figure 6.

IL-6 has anti-inflammatory effects as it inhibits TNF production and stimulates the production of IL-1ra and IL-10. IL-6 stimulates cortisol production and thereby induces neutrocytosis and lymphopenia. Abbreviations: IL-1ra, IL-1 receptor antagonist; TNF, tumor necrosis factor.

Figure 7.
Figure 7.

Cathepsin B and irisin cross the blood–brain barrier and stimulate BDNF production and hippocampal neurogenesis. IL-6 stimulates appetite and lipolysis and decreases visceral fat mass. Irisin, meteorin-like, and IL-6 have a role in “browning” of white adipose tissue. IL-15 improves aging skin. Decorin, IL-6, IGF-1 and FGF-2 positively regulate bone formation. Myostatin negatively regulate bone formation. Musclin, LIF, IL-4, IL-6, IL-7, and IL-15 promote muscle hypertrophy. Myostatin inhibits muscle hypertrophy. BDNF and IL-6 are involved in AMPK-mediated fat oxidation. IL-6 enhances insulin-stimulated glucose uptake and stimulates glucose output from the liver, but only during exercise. IL-6 increases insulin secretion by inducing the expression of GLP-1 by the L cells of the intestine. IL-6 has anti-inflammatory effects as it inhibits TNF production and stimulates the production of IL-1ra and IL-10. IL-6 stimulates cortisol production and thereby induces neutrocytosis and lymphopenia. FSTL-1 improves endothelial function and revascularization of ischemic blood vessels. Angiogenin, osteoprotegerin and IL-6 possess pancreatic β-cell protective actions against proinflammatory cytokines. Abbreviations: AMPK, 5′-AMP-activated protein kinase; BDNF, brain-derived neurotrophic factor; FGF-2, fibroblast growth factor 2; FGF-21, fibroblast growth factor 21; FSTL-1, follistatin-related protein 1; GLP-1, glucagon-like peptide 1; IGF-1, insulin-like growth factor I; IL-1ra, IL-1 receptor antagonist; LIF, leukemia inhibitory factor; TGF-β, transforming growth factor β; TNF, tumor necrosis factor.

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References

    1. Kjaer M, Secher NH, Bangsbo J, et al. Hormonal and metabolic responses to electrically induced cycling during epidural anesthesia in humans. J Appl Physiol (1985). 1996;80(6):2156-2162. - PubMed
    1. Mohr T, Andersen JL, Biering-Sørensen F, et al. Long-term adaptation to electrically induced cycle training in severe spinal cord injured individuals. Spinal Cord. 1997;35(1):1-16. - PubMed
    1. Goldstein M. Humoral nature of hypoglycemia in muscular activity. Am J Physiol. 1961;200:67-70.
    1. Pedersen BK, Steensberg A, Fischer C, et al. Searching for the exercise factor: is IL-6 a candidate? J Muscle Res Cell Motil. 2003;24(2-3):113-119. - PubMed
    1. Steensberg A, van Hall G, Osada T, Sacchetti M, Saltin B, Klarlund Pedersen B. Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6. J Physiol. 2000;529(Pt 1):237-242. - PMC - PubMed

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