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Influence of Paleolithic range contraction, admixture and long-distance dispersal on genetic gradients of modern humans in Asia - PubMed

. 2020 Jun;29(12):2150-2159.

doi: 10.1111/mec.15479. Epub 2020 Jun 14.

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Influence of Paleolithic range contraction, admixture and long-distance dispersal on genetic gradients of modern humans in Asia

Catarina Branco et al. Mol Ecol. 2020 Jun.

Abstract

Cavalli-Sforza and coauthors originally explored the genetic variation of modern humans throughout the world and observed an overall east-west genetic gradient in Asia. However, the specific environmental and population genetics processes causing this gradient were not formally investigated and promoted discussion in recent studies. Here we studied the influence of diverse environmental and population genetics processes on Asian genetic gradients and identified which could have produced the observed gradient. To do so, we performed extensive spatially-explicit computer simulations of genetic data under the following scenarios: (a) variable levels of admixture between Paleolithic and Neolithic populations, (b) migration through long-distance dispersal (LDD), (c) Paleolithic range contraction induced by the last glacial maximum (LGM), and (d) Neolithic range expansions from one or two geographic origins (the Fertile Crescent and the Yangzi and Yellow River Basins). Next, we estimated genetic gradients from the simulated data and we found that they were sensible to the analysed processes, especially to the range contraction induced by LGM and to the number of Neolithic expansions. Some scenarios were compatible with the observed east-west genetic gradient, such as the Paleolithic expansion with a range contraction induced by the LGM or two Neolithic range expansions from both the east and the west. In general, LDD increased the variance of genetic gradients among simulations. We interpreted the obtained gradients as a consequence of both allele surfing caused by range expansions and isolation by distance along the vast east-west geographic axis of this continent.

Keywords: human genetic gradients; last glacial maximum; long-distance dispersal; range contraction; range expansion; spatially-explicit simulations.

© 2020 John Wiley & Sons Ltd.

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REFERENCES

    1. Alves, I., Arenas, M., Currat, M., Hanulova, A. S., Sousa, V. C., Ray, N., & Excoffier, L. (2016). Long-distance dispersal shaped patterns of human genetic diversity in Eurasia. Molecular Biology and Evolution, 33(4), 946-958. https://doi.org/10.1093/molbev/msv332
    1. Ammerman, A. J., & Cavalli-Sforza, L. L. (1984). The Neolithic transition and the genetics of populations in Europe. Princeton, NJ: Princeton University Press.
    1. Arenas, M., François, O., Currat, M., Ray, N., & Excoffier, L. (2013). Influence of admixture and Paleolithic range contractions on current European diversity gradients. Molecular Biology and Evolution, 30(1), 57-61. https://doi.org/10.1093/molbev/mss203
    1. Arenas, M., Gorostiza, A., Baquero, J. M., Campoy, E., Branco, C., Rangel-Villalobos, H., & González-Martín, A. (2020). The early peopling of the Philippines based on mtDNA. Scientific Reports, 10(1), 4901. https://doi.org/10.1038/s41598-020-61793-7
    1. Arenas, M., Mona, S., Trochet, A., Sramkova Hanulova, A., Currat, M., Ray, N., … Excoffier, L. (2014). The scaling of genetic diversity in a changing and fragmented world. In: K. Henle (Ed.). Scaling in ecology and biodiversity conservation (pp. 55-60). Sofia, Bulgaria:Pensoft Publishers. https://doi.org/10.3897/ab.e1169

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