pubmed.ncbi.nlm.nih.gov

Recent Updates on Outbreaks of Shiga Toxin-Producing Escherichia coli and Its Potential Reservoirs - PubMed

  • ️Wed Jan 01 2020

Review

Recent Updates on Outbreaks of Shiga Toxin-Producing Escherichia coli and Its Potential Reservoirs

Jun-Seob Kim et al. Front Cell Infect Microbiol. 2020.

Abstract

Following infection with certain strains of Shiga toxin-producing Escherichia coli (STEC), particularly enterohemorrhagic ones, patients are at elevated risk for developing life-threatening extraintestinal complications, such as acute renal failure. Hence, these bacteria represent a public health concern in both developed and developing countries. Shiga toxins (Stxs) expressed by STEC are highly cytotoxic class II ribosome-inactivating proteins and primary virulence factors responsible for major clinical signs of Stx-mediated pathogenesis, including bloody diarrhea, hemolytic uremic syndrome (HUS), and neurological complications. Ruminant animals are thought to serve as critical environmental reservoirs of Stx-producing Escherichia coli (STEC), but other emerging or arising reservoirs of the toxin-producing bacteria have been overlooked. In particular, a number of new animal species from wildlife and aquaculture industries have recently been identified as unexpected reservoir or spillover hosts of STEC. Here, we summarize recent findings about reservoirs of STEC and review outbreaks of these bacteria both within and outside the United States. A better understanding of environmental transmission to humans will facilitate the development of novel strategies for preventing zoonotic STEC infection.

Keywords: HUS; STEC reservoir; Shiga toxin; Shiga toxin-producing Escherichia coli; environmental transmission.

Copyright © 2020 Kim, Lee and Kim.

PubMed Disclaimer

Figures

Figure 1
Figure 1

After ingestion of food or water contaminated with pathogenic STEC, Stxs may cross the intestinal epithelial barrier via M-cell uptake and transcytosis or paracellular transport. Once in the submucosa, the toxins activate innate immune cells, such as neutrophils or monocytes that act as “carrier” cells to deliver Stxs in the bloodstream and may also further exacerbate tissue injury via localized production of proinflammatory cytokines. Ultimately, the toxins are transferred to glomerular endothelial cells and tubular epithelial cells, which are rich in the toxin receptor Gb3. Damage to the kidney, the primary target organ, leads to D + HUS (diarrhea-associated hemolytic uremic syndrome).

Similar articles

Cited by

References

    1. Alam M. J., Zurek L. (2004). Association of Escherichia coli O157:H7 with houseflies on a cattle farm. Appl. Environ. Microbiol. 70, 7578–7580. 10.1128/AEM.70.12.7578-7580.2004 - DOI - PMC - PubMed
    1. Bardiau M., Gregoire F., Muylaert A., Nahayo A., Duprez J. N., Mainil J., et al. . (2010). Enteropathogenic (EPEC), enterohaemorragic (EHEC) and verotoxigenic (VTEC) Escherichia coli in wild cervids. J. Appl. Microbiol. 109, 2214–2222. 10.1111/j.1365-2672.2010.04855.x - DOI - PubMed
    1. Beutin L. (1999). Escherichia coli as a pathogen in dogs and cats. Vet. Res. 30, 285–298. - PubMed
    1. Beutin L., Geier D., Steinruck H., Zimmermann S., Scheutz F. (1993). Prevalence and some properties of verotoxin (Shiga-like toxin)-producing Escherichia coli in seven different species of healthy domestic animals. J. Clin. Microbiol. 31, 2483–2488. 10.1128/JCM.31.9.2483-2488.1993 - DOI - PMC - PubMed
    1. Blanco Crivelli X., Rumi M. V., Carfagnini J. C., Degregorio O., Bentancor A. B. (2012). Synanthropic rodents as possible reservoirs of shigatoxigenic Escherichia coli strains. Front. Cell. Infect Microbiol. 2:134. 10.3389/fcimb.2012.00134 - DOI - PMC - PubMed

Publication types

MeSH terms

Substances