pubmed.ncbi.nlm.nih.gov

Choroid Plexus: The Orchestrator of Long-Range Signalling Within the CNS - PubMed

  • ️Wed Jan 01 2020

Review

Choroid Plexus: The Orchestrator of Long-Range Signalling Within the CNS

Karol Kaiser et al. Int J Mol Sci. 2020.

Abstract

Cerebrospinal fluid (CSF) is the liquid that fills the brain ventricles. CSF represents not only a mechanical brain protection but also a rich source of signalling factors modulating diverse processes during brain development and adulthood. The choroid plexus (CP) is a major source of CSF and as such it has recently emerged as an important mediator of extracellular signalling within the brain. Growing interest in the CP revealed its capacity to release a broad variety of bioactive molecules that, via CSF, regulate processes across the whole central nervous system (CNS). Moreover, CP has been also recognized as a sensor, responding to altered composition of CSF associated with changes in the patterns of CNS activity. In this review, we summarize the recent advances in our understanding of the CP as a signalling centre that mediates long-range communication in the CNS. By providing a detailed account of the CP secretory repertoire, we describe how the CP contributes to the regulation of the extracellular environment-in the context of both the embryonal as well as the adult CNS. We highlight the role of the CP as an important regulator of CNS function that acts via CSF-mediated signalling. Further studies of CP-CSF signalling hold the potential to provide key insights into the biology of the CNS, with implications for better understanding and treatment of neuropathological conditions.

Keywords: cerebrospinal fluid; choroid plexus; secretion.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1

Schematic representation of choroid plexus secretome.

Similar articles

Cited by

References

    1. Carpenter E.M. The Choroid Plexus and Cerebrospinal Fluid: Emerging Roles in CNS Development, Maintenance, and Disease Progression. Academic Press; San Diego, CA, USA: 2016. Chapter 2-Development of Brain Ventricles and Choroid Plexus; pp. 15–27.
    1. Fame R.M., Cortés-Campos C., Sive H.L. Brain Ventricular System and Cerebrospinal Fluid Development and Function: Light at the End of the Tube. BioEssays. 2020;42:1900186. doi: 10.1002/bies.201900186. - DOI - PubMed
    1. Hindle S.J., Munji R.N., Dolghih E., Gaskins G., Orng S., Ishimoto H., Soung A., DeSalvo M., Kitamoto T., Keiser M.J., et al. Evolutionarily Conserved Roles for Blood-Brain Barrier Xenobiotic Transporters in Endogenous Steroid Partitioning and Behavior. Cell Rep. 2017;21:1304–1316. doi: 10.1016/j.celrep.2017.10.026. - DOI - PMC - PubMed
    1. Ghersi-Egea J.F., Strazielle N., Catala M., Silva-Vargas V., Doetsch F., Engelhardt B. Molecular anatomy and functions of the choroidal blood-cerebrospinal fluid barrier in health and disease. Acta Neuropathol. 2018;135:337–361. doi: 10.1007/s00401-018-1807-1. - DOI - PubMed
    1. Lehtinen M.K., Zappaterra M.W., Chen X., Yang Y.J., Hill A.D., Lun M., Maynard T., Gonzalez D., Kim S., Ye P., et al. The cerebrospinal fluid provides a proliferative niche for neural progenitor cells. Neuron. 2011;69:893–905. doi: 10.1016/j.neuron.2011.01.023. - DOI - PMC - PubMed

Publication types

MeSH terms

LinkOut - more resources