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Do ABC transporters regulate plasma membrane organization? - PubMed

  • ️Wed Jan 01 2020

Review

Do ABC transporters regulate plasma membrane organization?

Ambroise Wu et al. Cell Mol Biol Lett. 2020.

Abstract

The plasma membrane (PM) spatiotemporal organization is one of the major factors controlling cell signaling and whole-cell homeostasis. The PM lipids, including cholesterol, determine the physicochemical properties of the membrane bilayer and thus play a crucial role in all membrane-dependent cellular processes. It is known that lipid content and distribution in the PM are not random, and their transversal and lateral organization is highly controlled. Mainly sphingolipid- and cholesterol-rich lipid nanodomains, historically referred to as rafts, are extremely dynamic "hot spots" of the PM controlling the function of many cell surface proteins and receptors. In the first part of this review, we will focus on the recent advances of PM investigation and the current PM concept. In the second part, we will discuss the importance of several classes of ABC transporters whose substrates are lipids for the PM organization and dynamics. Finally, we will briefly present the significance of lipid ABC transporters for immune responses.

Keywords: ABC transporter; Cholesterol; Membrane (nano)domains; Phospholipids; Plasma membrane; Rafts.

© The Author(s) 2020.

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Conflict of interest statement

Competing interestsThe authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1

Schematic representation of the cell with localization of lipid-related ABC transporters together whit their substrates (in parenthesis). Ch – cholesterol; PC – phosphatidylcholine; PS – phosphatidylserine; SM – sphingomyelin; SL – sphingolipids; Surf. – surfactant; VLCFAs – very-long-chain fatty acids; PUFAs – polyunsaturated fatty acids

Fig. 2
Fig. 2

Heat map display of murine ABC transporter normalized expression level in five highly purified immunocyte populations based upon ImmGen Deep RNA-seq data [151] (GEO accession: GSE122597), namely NK Cells, Follicular B, Naive CD4+, αβT, γδT cells, and peritoneal macrophages

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