pubmed.ncbi.nlm.nih.gov

A comprehensive review of therapeutic approaches available for the treatment of cholera - PubMed

Review

. 2020 Dec;72(12):1715-1731.

doi: 10.1111/jphp.13344. Epub 2020 Jul 31.

Affiliations

Review

A comprehensive review of therapeutic approaches available for the treatment of cholera

Francisca B M Sousa et al. J Pharm Pharmacol. 2020 Dec.

Abstract

Objectives: The oral rehydration solution is the most efficient method to treat cholera; however, it does not interfere in the action mechanism of the main virulence factor produced by Vibrio cholerae, the cholera toxin (CT), and this disease still stands out as a problem for human health worldwide. This review aimed to describe therapeutic alternatives available in the literature, especially those related to the search for molecules acting upon the physiopathology of cholera.

Key findings: New molecules have offered a protection effect against diarrhoea induced by CT or even by infection from V. cholerae. The receptor regulator cystic fibrosis channel transmembrane (CFTR), monosialoganglioside (GM1), enkephalinase, AMP-activated protein kinase (AMPK), inhibitors of expression of virulence factors and activators of ADP-ribosylarginine hydrolase are the main therapeutic targets studied. Many of these molecules or extracts still present unclear action mechanisms.

Conclusions: Knowing therapeutic alternatives and their molecular mechanisms for the treatment of cholera could guide us to develop a new drug that could be used in combination with the rehydration solution.

Keywords: cholera; cholera toxin; molecular mechanism.

© 2020 Royal Pharmaceutical Society.

PubMed Disclaimer

Similar articles

Cited by

References

    1. Harris JB et al. Cholera. Lancet 2012; 379: 2466-2476.
    1. Davies HG et al. Cholera - management and prevention. J Infect 2017; 74: S66-S73.
    1. Jutla A et al. Natural disasters and cholera outbreaks: current understanding and future outlook. Curr Environ Health Rep 2017; 4: 99-107.
    1. Lippi D et al. Cholera. Microbiol Spectr 2016; 4: 1-6.
    1. CDC (Centers for Disease Control and Prevention). Cholera-Vibrio cholerae Infection. 2018. https://www.cdc.gov/cholera/treatment/index.html. Accessed 23 October 2018.

Publication types

MeSH terms

Substances