Uric acid and cardiovascular disease: A clinical review - PubMed

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• PMID: 33388217
• DOI: 10.1016/j.jjcc.2020.12.013

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Review

Uric acid and cardiovascular disease: A clinical review

Yuichi Saito et al. J Cardiol. 2021 Jul.

Free article

Abstract

Uric acid, the end-product of purine metabolism in humans, is not only a cause of gout, but also may play roles in developing cardiovascular diseases such as hypertension, atrial fibrillation, chronic kidney disease, heart failure, coronary artery disease, and cardiovascular death. Several clinical investigations have reported serum uric acid as a predictive marker for cardiovascular outcomes. Although the causal relationship of hyperuricemia to cardiovascular diseases remains controversial, there has been a growing interest in uric acid because of the increased prevalence of hyperuricemia worldwide. This review article summarizes current evidence concerning the relation between hyperuricemia and cardiovascular diseases.

Keywords: Cardiovascular disease; Outcome; Uric acid.

Conflict of interest statement

Declaration of Competing Interest Yuichi Saito, Atsushi Tanaka, and Yoshio Kobayashi declare no conflicts of interest to disclose. Koichi Node reports research grants from Asahi Kasei, Astellas, Boehringer Ingelheim Japan, Mitsubishi Tanabe Pharma, Teijin Pharma, and Terumo, scholarship grants from Astellas, Bayer Yakuhin, Bristol-Myers Squibb, Daiichi Sankyo Healthcare, Takeda Pharmaceutical, Teijin Pharma, and honoraria from Astellas, AstraZeneca, Bayer Yakuhin, Boehringer Ingelheim Japan, Daiichi Sankyo Healthcare, Eli Lilly Japan, Kowa, Mitsubishi Tanabe Pharma, MSD, Novo Nordisk Pharma, Ono Pharmaceutical, Takeda Pharmaceutical, and Teijin Pharma.

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