pubmed.ncbi.nlm.nih.gov

Long Noncoding RNAs as Innovative Urinary Diagnostic Biomarkers - PubMed

Review

Long Noncoding RNAs as Innovative Urinary Diagnostic Biomarkers

Giulia Brisotto et al. Methods Mol Biol. 2021.

Abstract

The characterization of circulating tumor cells (CTCs) is now widely studied as a promising source of cancer-derived biomarkers because of their role in tumor formation and progression. However, CTCs analysis presents some limitations and no standardized method for CTCs isolation from urine has been defined so far. In fact, besides blood, urine represents an ideal source of noninvasive biomarkers, especially for the early detection of genitourinary tumors. Besides CTCs, long noncoding RNAs (lncRNAs) have also been proposed as potential noninvasive biomarkers, and the evaluation of the diagnostic accuracy of urinary lncRNAs has dramatically increased over the last years, with many studies being published. Therefore, this review provides an update on the clinical utility of urinary lncRNAs as novel biomarkers for the diagnosis of bladder and prostate cancers.

Keywords: Bladder cancer; Diagnostic biomarkers; Long noncoding RNAs; Prostate cancer.

PubMed Disclaimer

Similar articles

Cited by

References

    1. Perakis S, Speicher MR (2017) Emerging concepts in liquid biopsies. BMC Med 15(1):75. https://doi.org/10.1186/s12916-017-0840-6 - DOI - PubMed - PMC
    1. Arneth B (2018) Update on the types and usage of liquid biopsies in the clinical setting: a systematic review. BMC Cancer 18(1):527. https://doi.org/10.1186/s12885-018-4433-3 - DOI - PubMed - PMC
    1. Bratulic S, Gatto F, Nielsen J (2019) The translational status of cancer liquid biopsies. Regen Eng Transl Med. https://doi.org/10.1007/s40883-019-00141-2
    1. Castro-Giner F, Gkountela S, Donato C, Alborelli I, Quagliata L, Ng CKY, Piscuoglio S, Aceto N (2018) Cancer diagnosis using a liquid biopsy: challenges and expectations. Diagnostics (Basel, Switzerland) 8(2):31. https://doi.org/10.3390/diagnostics8020031 - DOI
    1. Ferreira MM, Ramani VC, Jeffrey SS (2016) Circulating tumor cell technologies. Mol Oncol 10(3):374–394. https://doi.org/10.1016/j.molonc.2016.01.007 - DOI - PubMed - PMC

Publication types

MeSH terms

Substances

LinkOut - more resources