Cardiac Rehabilitation With Dynamic Exercise Increases the Number of Muse Cells in the Peripheral Blood of Patients With Heart Disease - PubMed
- ️Mon Jan 01 2018
Cardiac Rehabilitation With Dynamic Exercise Increases the Number of Muse Cells in the Peripheral Blood of Patients With Heart Disease
Shingo Minatoguchi et al. Circ Rep. 2018.
Abstract
Background: It is still unclear whether dynamic exercise increases the number of Muse cells, pluripotent stem cells, in the peripheral blood. Methods and Results: The number of Muse cells, SSEA3+ and CD105+ double-positive cells, in the peripheral blood was measured using FACS before and after 40 min of cardiac rehabilitation with dynamic exercise in 6 patients with heart disease. The number of Muse cells significantly increased after cardiac rehabilitation in all patients. Muse cell mobilization may be related to the beneficial clinical outcome of cardiac rehabilitation. Conclusions: Cardiac rehabilitation increases the number of Muse cells in the peripheral blood.
Keywords: Cardiac rehabilitation; Dynamic exercise; Muse cell.
Copyright © 2019, THE JAPANESE CIRCULATION SOCIETY.
Conflict of interest statement
The authors declare no conflicts of interest.
Figures
(A) A typical case involving a patient with old myocardial infarction. SSEA3+/CD105+ double-positive cells were measured in the monocyte area on fluorescence-activated cell sorting before and after cardiac rehabilitation with dynamic exercise. Bold green rectangle, CD105-positive cells in the monocyte area; right-upper red rectangle, SSEA3+/CD105+ double-positive cells. (B) Distribution of fluorescence intensity in SSEA3+ cells within the gating area (monocyte and CD105+ areas). M1, SSEA3+/CD105+ double-positive multilineage-differentiating stress-enduring (Muse) cells. FITC, fluorescein isothiocyanate; FSC, forware scatter; SSC, side scatter.
(A) Absolute and (B) mean±SD number of multilineage-differentiating stress-enduring (Muse) cells in peripheral blood before and after cardiac rehabilitation (n=6).
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