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The Potential Role of miRNAs as Predictive Biomarkers in Neurodevelopmental Disorders - PubMed

Review

. 2021 Jul;71(7):1338-1355.

doi: 10.1007/s12031-021-01825-7. Epub 2021 Mar 27.

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Review

The Potential Role of miRNAs as Predictive Biomarkers in Neurodevelopmental Disorders

Iman Imtiyaz Ahmed Juvale et al. J Mol Neurosci. 2021 Jul.

Erratum in

Abstract

Neurodevelopmental disorders are defined as a set of abnormal brain developmental conditions marked by the early childhood onset of cognitive, behavioral, and functional deficits leading to memory and learning problems, emotional instability, and impulsivity. Autism spectrum disorder, attention-deficit/hyperactivity disorder, Tourette syndrome, fragile X syndrome, and Down's syndrome are a few known examples of neurodevelopmental disorders. Although they are relatively common in both developed and developing countries, very little is currently known about their underlying molecular mechanisms. Both genetic and environmental factors are known to increase the risk of neurodevelopmental disorders. Current diagnostic and screening tests for neurodevelopmental disorders are not reliable; hence, individuals with neurodevelopmental disorders are often diagnosed in the later stages. This negatively affects their prognosis and quality of life, prompting the need for a better diagnostic biomarker. Recent studies on microRNAs and their altered regulation in diseases have shed some light on the possible role they could play in the development of the central nervous system. This review attempts to elucidate our current understanding of the role that microRNAs play in neurodevelopmental disorders with the hope of utilizing them as potential biomarkers in the future.

Keywords: Attention-deficit/hyperactivity disorder; Autism spectrum disorder; Down’s syndrome; Fragile X syndrome; MicroRNA; Tourette syndrome.

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References

    1. Abelson J, Kwan K, O’Roak B, Baek D, Stillman A, Morgan T, Mathews C, Pauls D, Rasin M, Gunel M, Davis N, Ercan-Sencicek A, Guez D, Spertus J, Leckman J, Dure L, Kurlan R, Singer H, Gilbert D, Farhi A, Louvi A, Lifton R, Sestan N, State M (2005) Sequence variants in SLITRK1 are associated with Tourette’s syndrome. Science 310(5746):317–320 - PubMed
    1. Abu-Elneel K, Liu T, Gazzaniga FS, Nishimura Y, Wall DP, Geschwind DH, Lao K, Kosik KS (2008) Heterogeneous dysregulation of microRNAs across the autism spectrum. Neurogenetics 9:153–161 - PubMed
    1. Adams CM, Hiebert SW, Eischen CM (2016) Myc induces miRNA-mediated apoptosis in response to HDAC inhibition in hematologic malignancies. Can Res 76(3):736–748
    1. Agnew-Blais J, Polanczyk G, Danese A, Wertz J, Moffitt T, Arseneault L (2018) Young adult mental health and functional outcomes among individuals with remitted, persistent and late-onset ADHD. Br J Psychiatry 213(3):526–534 - PubMed - PMC
    1. Ai J, Sun L-H, Che H, Zhang R, Zhang T-Z, Wu W-C, Su X-L, Chen X, Yang G, Li K (2013) MicroRNA-195 protects against dementia induced by chronic brain hypoperfusion via its anti-amyloidogenic effect in rats. J Neurosci 33:3989–4001 - PubMed - PMC

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