Challenges and opportunities of pharmaceutical cocrystals: a focused review on non-steroidal anti-inflammatory drugs - PubMed
- ️Fri Jan 01 2021
Review
. 2021 Feb 9;12(5):705-721.
doi: 10.1039/d0md00400f. eCollection 2021 May 26.
Affiliations
- PMID: 34124670
- PMCID: PMC8152597
- DOI: 10.1039/d0md00400f
Review
Challenges and opportunities of pharmaceutical cocrystals: a focused review on non-steroidal anti-inflammatory drugs
Utsav Garg et al. RSC Med Chem. 2021.
Abstract
The focus of the review is to discuss the relevant and essential aspects of pharmaceutical cocrystals in both academia and industry with an emphasis on non-steroidal anti-inflammatory drugs (NSAIDs). Although cocrystals have been prepared for a plethora of drugs, NSAID cocrystals are focused due to their humongous application in different fields of medication such as antipyretic, anti-inflammatory, analgesic, antiplatelet, antitumor, and anti-carcinogenic drugs. The highlights of the review are (a) background of cocrystals and other solid forms of an active pharmaceutical ingredient (API) based on the principles of crystal engineering, (b) why cocrystals are an excellent opportunity in the pharma industry, (c) common methods of preparation of cocrystals from the lab scale to bulk quantity, (d) some latest case studies of NSAIDs which have shown better physicochemical properties for example; mechanical properties (tabletability), hydration, solubility, bioavailability, and permeability, and (e) latest guidelines of the US FDA and EMA opening new opportunities and challenges.
This journal is © The Royal Society of Chemistry.
Conflict of interest statement
There are no conflicts to declare.
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References
-
- Rao V. M., Sanghvi R. and Zhu H., in Developing Solid Oral Dosage Forms, Elsevier, 2009, pp. 1–24
-
- Kapoor D., Maheshwari R., Verma K., Sharma S., Pethe A. and Tekade R. K., in Drug Delivery Systems, Elsevier, 2020, pp. 1–45
-
- Zografi G. Drug Dev. Ind. Pharm. 1988;14:1905–1926. doi: 10.3109/03639048809151997. - DOI
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