New Perspectives on the Biogenesis of Viral Inclusion Bodies in Negative-Sense RNA Virus Infections - PubMed

Figure 3

Summary of inclusion body (IB) formation upon infection with NSV. Small IBs indicate minimal required viral proteins for IB formation, while larger IBs represent mature IBs as biomolecular condensates formed by LLPS. * IB formation by LLPS suspected. Different steps of the viral life cycle taking place in IBs as indicated. In red cellular proteins that localize to IBs. RABV, Rabies virus [106]. VSV, vesicular stomatitis virus [103,107]. RSV, Respiratory syncytial virus [101,108]. MeV, Measles virus [109,110]. NiV, Nipah virus [111]. EBOV, Ebola virus [104,105]. MARV, Marburg virus [112,113]. IAV, Influenza A virus [114,115]. IBAG, IB associated granules. IBperi, perinuclear IB. IBpm, IB plasma membrane. NC, nucleocapsid. HSP70/90, heat shock protein 70/90. FAK, focal adhesion kinase. G3BP, Ras GTPase-activating protein-binding protein 1. TIA1, T-cell restricted intracellular antigen 1. TIAR, TIA1-related protein. PCBP2, Poly(RC) Binding Protein 2. p65, NF-κB subunit p65. p65 MAPK, p38 mitogen-activated protein kinase. OGT, O-linked N-acetylglucosamine transferase. MAVS, mitochondrial antiviral-signaling protein. MDA5, melanoma differentiation-associated protein 5. WDR5, WD repeat protein 5. Tsg101, tumor susceptibility gene 101. IQGAP1, Ras GTPase-activating-like protein 1. NXF1, Nuclear RNA export factor 1. CAD, carbamoyl-phosphate synthetase 2, aspar-tate transcarbamylase, and dihydroorotase. SRPK1, Serine-arginine protein kinase. PP2A-B56, protein phosphatase 2 B56 subunit. eIF4G, Eukaryotic translation initiation factor 4 G. eIF3, Eukaryotic initiation factor 3. PABP, Poly(A)-binding protein. Rab11, Ras-related protein Rab-11.