The Entorhinal Cortex and Adult Neurogenesis in Major Depression - PubMed
- ️Fri Jan 01 2021
Review
The Entorhinal Cortex and Adult Neurogenesis in Major Depression
Il Bin Kim et al. Int J Mol Sci. 2021.
Abstract
Depression is characterized by impairments in adult neurogenesis. Reduced hippocampal function, which is suggestive of neurogenesis impairments, is associated with depression-related phenotypes. As adult neurogenesis operates in an activity-dependent manner, disruption of hippocampal neurogenesis in depression may be a consequence of neural circuitry impairments. In particular, the entorhinal cortex is known to have a regulatory effect on the neural circuitry related to hippocampal function and adult neurogenesis. However, a comprehensive understanding of how disruption of the neural circuitry can lead to neurogenesis impairments in depression remains unclear with respect to the regulatory role of the entorhinal cortex. This review highlights recent findings suggesting neural circuitry-regulated neurogenesis, with a focus on the potential role of the entorhinal cortex in hippocampal neurogenesis in depression-related cognitive and emotional phenotypes. Taken together, these findings may provide a better understanding of the entorhinal cortex-regulated hippocampal neurogenesis model of depression.
Keywords: cognition; depression; emotion; entorhinal cortex; hippocampus; neural circuitry; neurogenesis.
Conflict of interest statement
The authors declare no conflict of interest.
Figures

Hypothetical concept of the role of entorhinal cortex-regulated hippocampal neurogenesis in the manifestation of depression-related symptoms. The glutamatergic stimulation from the entorhinal cortex to the dentate gyrus of the hippocampus is illustrated. The glutamatergic stimulation regulates the maturation process of the dentate granule cells during hippocampal neurogenesis, which in turn affects cognition and emotion.

Supportive findings for entorhinal cortex-regulated hippocampal neurogenesis for cognition and emotion. (a), Entorhinal cortex-regulated hippocampal neurogenesis for memory function. Deep brain stimulation of the entorhinal cortex leads to increased neurogenesis, which presents as reduced time to escape in the water navigation maze task. (b), Entorhinal cortex-regulated hippocampal neurogenesis for pattern separation. Chemogenetic stimulation of the entorhinal cortex leads to enhanced neurogenesis in Trip8b-knockdown mice, which presents as improved discrimination between similar contexts in a fear conditioning task. (c), Entorhinal cortex-regulated hippocampal neurogenesis for emotion regulation. Chemogenetic stimulation of entorhinal cortex leads to improved neurogenesis in Trip8b-knockdown mice, which presents as an immediate response to a given food in the novelty-suppressed feeding task.

Supportive findings for entorhinal cortex-regulated hippocampal neurogenesis for cognition and emotion. (a), Entorhinal cortex-regulated hippocampal neurogenesis for memory function. Deep brain stimulation of the entorhinal cortex leads to increased neurogenesis, which presents as reduced time to escape in the water navigation maze task. (b), Entorhinal cortex-regulated hippocampal neurogenesis for pattern separation. Chemogenetic stimulation of the entorhinal cortex leads to enhanced neurogenesis in Trip8b-knockdown mice, which presents as improved discrimination between similar contexts in a fear conditioning task. (c), Entorhinal cortex-regulated hippocampal neurogenesis for emotion regulation. Chemogenetic stimulation of entorhinal cortex leads to improved neurogenesis in Trip8b-knockdown mice, which presents as an immediate response to a given food in the novelty-suppressed feeding task.
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