pubmed.ncbi.nlm.nih.gov

The Entorhinal Cortex and Adult Neurogenesis in Major Depression - PubMed

  • ️Fri Jan 01 2021

Review

The Entorhinal Cortex and Adult Neurogenesis in Major Depression

Il Bin Kim et al. Int J Mol Sci. 2021.

Abstract

Depression is characterized by impairments in adult neurogenesis. Reduced hippocampal function, which is suggestive of neurogenesis impairments, is associated with depression-related phenotypes. As adult neurogenesis operates in an activity-dependent manner, disruption of hippocampal neurogenesis in depression may be a consequence of neural circuitry impairments. In particular, the entorhinal cortex is known to have a regulatory effect on the neural circuitry related to hippocampal function and adult neurogenesis. However, a comprehensive understanding of how disruption of the neural circuitry can lead to neurogenesis impairments in depression remains unclear with respect to the regulatory role of the entorhinal cortex. This review highlights recent findings suggesting neural circuitry-regulated neurogenesis, with a focus on the potential role of the entorhinal cortex in hippocampal neurogenesis in depression-related cognitive and emotional phenotypes. Taken together, these findings may provide a better understanding of the entorhinal cortex-regulated hippocampal neurogenesis model of depression.

Keywords: cognition; depression; emotion; entorhinal cortex; hippocampus; neural circuitry; neurogenesis.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1

Hypothetical concept of the role of entorhinal cortex-regulated hippocampal neurogenesis in the manifestation of depression-related symptoms. The glutamatergic stimulation from the entorhinal cortex to the dentate gyrus of the hippocampus is illustrated. The glutamatergic stimulation regulates the maturation process of the dentate granule cells during hippocampal neurogenesis, which in turn affects cognition and emotion.

Figure 2
Figure 2

Supportive findings for entorhinal cortex-regulated hippocampal neurogenesis for cognition and emotion. (a), Entorhinal cortex-regulated hippocampal neurogenesis for memory function. Deep brain stimulation of the entorhinal cortex leads to increased neurogenesis, which presents as reduced time to escape in the water navigation maze task. (b), Entorhinal cortex-regulated hippocampal neurogenesis for pattern separation. Chemogenetic stimulation of the entorhinal cortex leads to enhanced neurogenesis in Trip8b-knockdown mice, which presents as improved discrimination between similar contexts in a fear conditioning task. (c), Entorhinal cortex-regulated hippocampal neurogenesis for emotion regulation. Chemogenetic stimulation of entorhinal cortex leads to improved neurogenesis in Trip8b-knockdown mice, which presents as an immediate response to a given food in the novelty-suppressed feeding task.

Figure 2
Figure 2

Supportive findings for entorhinal cortex-regulated hippocampal neurogenesis for cognition and emotion. (a), Entorhinal cortex-regulated hippocampal neurogenesis for memory function. Deep brain stimulation of the entorhinal cortex leads to increased neurogenesis, which presents as reduced time to escape in the water navigation maze task. (b), Entorhinal cortex-regulated hippocampal neurogenesis for pattern separation. Chemogenetic stimulation of the entorhinal cortex leads to enhanced neurogenesis in Trip8b-knockdown mice, which presents as improved discrimination between similar contexts in a fear conditioning task. (c), Entorhinal cortex-regulated hippocampal neurogenesis for emotion regulation. Chemogenetic stimulation of entorhinal cortex leads to improved neurogenesis in Trip8b-knockdown mice, which presents as an immediate response to a given food in the novelty-suppressed feeding task.

Similar articles

Cited by

References

    1. Hay S.I., Jayaraman S.P., Truelsen T., Sorensen R.J., Millear A., Giussani G., Beghi E. GBD 2015 disease and injury incidence and prevalence collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: A systematic analysis for the global burden of disease study 2015 (vol 388, pg 1545, 2016) Lancet. 2017;389:E1. - PMC - PubMed
    1. World Health Organization . Depression and Other Common Mental Disorders: Global Health Estimates. World Health Organization; Geneva, Switzerland: 2017.
    1. Trivedi M.H. Modeling predictors, moderators and mediators of treatment outcome and resistance in depression. Biol. Psychiatry. 2013;74:2–4. doi: 10.1016/j.biopsych.2013.05.009. - DOI - PubMed
    1. Park S.-C., Shinfuku N., Maramis M.M., Lee M.-S., Park Y.C. Adjunctive antipsychotic prescriptions for outpatients with depressive disorders in Asia: The research on Asian psychotropic prescription patterns for antidepressants (REAP-AD) study. Am. J. Psychiatry. 2015;172:684–685. doi: 10.1176/appi.ajp.2015.14121590. - DOI - PubMed
    1. Kupfer D.J., Frank E., Phillips M.L. Major depressive disorder: New clinical, neurobiological, and treatment perspectives. Focus. 2016;14:266–276. doi: 10.1176/appi.focus.140208. - DOI - PMC - PubMed

Publication types

MeSH terms