Immunohistochemical identification of HTLV-III antigen in brains of patients with AIDS - PubMed

Immunohistochemical identification of HTLV-III antigen in brains of patients with AIDS

D H Gabuzda et al. Ann Neurol. 1986 Sep.

Abstract

Human T-cell lymphotropic virus type III (HTLV-III) has been isolated from neural tissues and cerebrospinal fluid (CSF) of patients with neurological syndromes associated with the acquired immune deficiency syndrome (AIDS) and the virus may be directly involved in the pathogenesis of the syndromes. To detect HTLV-III antigen in neural tissues from patients with AIDS, immunoperoxidase studies using a goat anti-HTLV-III serum were performed on frozen tissue sections of brain, spinal cord, and nerve from 13 patients with AIDS or HTLV-III-related neurological syndromes. HTLV-III was cultured from neural tissues or CSF in 11 of 13 of these patients. HTLV-III antigen was detected in the brains of 5 patients with AIDS and in none of the 13 non-AIDS control subjects. Rare positively stained cells were seen, frequently associated with capillaries and often located near microglial nodules. Morphologically, the cells resembled monocyte/macrophages and were found most frequently in the cortex of the frontal, temporal, and parietal lobes. These results provide further evidence that the subacute encephalitis of AIDS is associated with central nervous system infection by HTLV-III and that monocyte/macrophages are among the infected cell populations.

Similar articles

• Isolation of HTLV-III from cerebrospinal fluid and neural tissues of patients with neurologic syndromes related to the acquired immunodeficiency syndrome.

  Ho DD, Rota TR, Schooley RT, Kaplan JC, Allan JD, Groopman JE, Resnick L, Felsenstein D, Andrews CA, Hirsch MS. Ho DD, et al. N Engl J Med. 1985 Dec 12;313(24):1493-7. doi: 10.1056/NEJM198512123132401. N Engl J Med. 1985. PMID: 2999591

• AIDS subacute encephalitis. Identification of HIV-infected cells.

  Vazeux R, Brousse N, Jarry A, Henin D, Marche C, Vedrenne C, Mikol J, Wolff M, Michon C, Rozenbaum W, et al. Vazeux R, et al. Am J Pathol. 1987 Mar;126(3):403-10. Am J Pathol. 1987. PMID: 3548405 Free PMC article.

• Presence of HTLV-III in tears and cells from the eyes of AIDS patients.

  Ablashi DV, Sturzenegger S, Hunter EA, Palestine AG, Fujikawa LS, Kim MK, Nussenblatt RB, Markham PD, Salahuddin SZ. Ablashi DV, et al. J Exp Pathol. 1987 Summer;3(4):693-703. J Exp Pathol. 1987. PMID: 3483881

• The neuropathology of adult HIV infection.

  Bell JE. Bell JE. Rev Neurol (Paris). 1998 Dec;154(12):816-29. Rev Neurol (Paris). 1998. PMID: 9932303 Review.

Cited by

• Localization of simian immunodeficiency virus in the central nervous system of rhesus monkeys.

  Lackner AA, Smith MO, Munn RJ, Martfeld DJ, Gardner MB, Marx PA, Dandekar S. Lackner AA, et al. Am J Pathol. 1991 Sep;139(3):609-21. Am J Pathol. 1991. PMID: 1716047 Free PMC article.

• CD4-independent, productive infection of a neuronal cell line by human immunodeficiency virus type 1.

  Li XL, Moudgil T, Vinters HV, Ho DD. Li XL, et al. J Virol. 1990 Mar;64(3):1383-7. doi: 10.1128/JVI.64.3.1383-1387.1990. J Virol. 1990. PMID: 2304148 Free PMC article.

• Chronic HIV encephalitis--II. Clinical aspects.

  Poser S, Lüer W, Eichenlaub D, Pohle HD, Weber T, Jürgens S, Felgenhauer K. Poser S, et al. Klin Wochenschr. 1988 Jan 4;66(1):26-31. doi: 10.1007/BF01735209. Klin Wochenschr. 1988. PMID: 3343805

• Molecular characterization of human immunodeficiency virus type 1 cloned directly from uncultured human brain tissue: identification of replication-competent and -defective viral genomes.

  Li Y, Kappes JC, Conway JA, Price RW, Shaw GM, Hahn BH. Li Y, et al. J Virol. 1991 Aug;65(8):3973-85. doi: 10.1128/JVI.65.8.3973-3985.1991. J Virol. 1991. PMID: 1830110 Free PMC article.

• Cytokines and arachidonic metabolites produced during human immunodeficiency virus (HIV)-infected macrophage-astroglia interactions: implications for the neuropathogenesis of HIV disease.

  Genis P, Jett M, Bernton EW, Boyle T, Gelbard HA, Dzenko K, Keane RW, Resnick L, Mizrachi Y, Volsky DJ, et al. Genis P, et al. J Exp Med. 1992 Dec 1;176(6):1703-18. doi: 10.1084/jem.176.6.1703. J Exp Med. 1992. PMID: 1460427 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Wiley

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information