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The Origins and Functions of De Novo Genes: Against All Odds? - PubMed

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Review

The Origins and Functions of De Novo Genes: Against All Odds?

Caroline M Weisman. J Mol Evol. 2022 Aug.

Abstract

"De novo" genes evolve from previously non-genic DNA. This strikes many of us as remarkable, because it seems extraordinarily unlikely that random sequence would produce a functional gene. How is this possible? In this two-part review, I first summarize what is known about the origins and molecular functions of the small number of de novo genes for which such information is available. I then speculate on what these examples may tell us about how de novo genes manage to emerge despite what seem like enormous opposing odds.

Keywords: De novo genes; Evolutionary novelty; Gene birth; Genetic novelty; Lineage-specific genes; Taxonomically-restricted genes.

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References

1. Abel EV, et al. The Notch pathway is important in maintaining the cancer stem cell population in pancreatic cancer. PLoS ONE. 2014;9(3):e91983. doi: 10.1371/journal.pone.0091983. - DOI - PMC - PubMed
1. An G, et al. Cloning and characterization of UROC28, a novel gene overexpressed in prostate, breast, and bladder cancers. Can Res. 2000;60(24):7014–7020. - PubMed
1. Andersson DI, Jerlström-Hultqvist J, Näsvall J. Evolution of new functions de novo and from preexisting genes. Cold Spring Harbor Perspect Biol. 2015;7(6):a017996. doi: 10.1101/cshperspect.a017996. - DOI - PMC - PubMed
1. Bao Z, et al. Identification of novel growth regulators in plant populations expressing random peptides. Plant Physiol. 2017;175(2):619–627. - PMC - PubMed
1. Barabási A-L, Albert R. Emergence of scaling in random networks. Science. 1999;286(5439):509–512. doi: 10.1126/science.286.5439.509. - DOI - PubMed

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