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The codon Adaptation Index--a measure of directional synonymous codon usage bias, and its potential applications - PubMed

  • ️Thu Jan 01 1987

Comparative Study

The codon Adaptation Index--a measure of directional synonymous codon usage bias, and its potential applications

P M Sharp et al. Nucleic Acids Res. 1987.

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Abstract

A simple, effective measure of synonymous codon usage bias, the Codon Adaptation Index, is detailed. The index uses a reference set of highly expressed genes from a species to assess the relative merits of each codon, and a score for a gene is calculated from the frequency of use of all codons in that gene. The index assesses the extent to which selection has been effective in moulding the pattern of codon usage. In that respect it is useful for predicting the level of expression of a gene, for assessing the adaptation of viral genes to their hosts, and for making comparisons of codon usage in different organisms. The index may also give an approximate indication of the likely success of heterologous gene expression.

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References

    1. Nucleic Acids Res. 1981 Jan 10;9(1):r43-74 - PubMed
    1. Mol Biol Evol. 1985 Jan;2(1):13-34 - PubMed
    1. J Mol Biol. 1981 Feb 15;146(1):1-21 - PubMed
    1. Proc Natl Acad Sci U S A. 1981 Sep;78(9):5739-43 - PubMed
    1. J Biol Chem. 1982 Feb 25;257(4):2009-15 - PubMed

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