pubmed.ncbi.nlm.nih.gov

International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data - PubMed

  • ️Sat Jan 01 2022

. 2022 Sep 15;140(11):1200-1228.

doi: 10.1182/blood.2022015850.

Attilio Orazi  2 , Robert P Hasserjian  3 , Michael J Borowitz  4 , Katherine R Calvo  5 , Hans-Michael Kvasnicka  6 , Sa A Wang  7 , Adam Bagg  8 , Tiziano Barbui  9 , Susan Branford  10 , Carlos E Bueso-Ramos  7 , Jorge E Cortes  11 , Paola Dal Cin  12 , Courtney D DiNardo  7 , Hervé Dombret  13 , Eric J Duncavage  14 , Benjamin L Ebert  15 , Elihu H Estey  16 , Fabio Facchetti  17 , Kathryn Foucar  18 , Naseema Gangat  19 , Umberto Gianelli  20 , Lucy A Godley  1 , Nicola Gökbuget  21 , Jason Gotlib  22 , Eva Hellström-Lindberg  23 , Gabriela S Hobbs  3 , Ronald Hoffman  24 , Elias J Jabbour  7 , Jean-Jacques Kiladjian  13 , Richard A Larson  1 , Michelle M Le Beau  1 , Mignon L-C Loh  25 , Bob Löwenberg  26 , Elizabeth Macintyre  27 , Luca Malcovati  28 , Charles G Mullighan  29 , Charlotte Niemeyer  30 , Olatoyosi M Odenike  1 , Seishi Ogawa  31 , Alberto Orfao  32 , Elli Papaemmanuil  33 , Francesco Passamonti  28 , Kimmo Porkka  34 , Ching-Hon Pui  29 , Jerald P Radich  35 , Andreas Reiter  36 , Maria Rozman  37 , Martina Rudelius  38 , Michael R Savona  39 , Charles A Schiffer  40 , Annette Schmitt-Graeff  41 , Akiko Shimamura  15   42 , Jorge Sierra  43 , Wendy A Stock  1 , Richard M Stone  15 , Martin S Tallman  44 , Jürgen Thiele  45 , Hwei-Fang Tien  46 , Alexandar Tzankov  47 , Alessandro M Vannucchi  48 , Paresh Vyas  49 , Andrew H Wei  50 , Olga K Weinberg  51 , Agnieszka Wierzbowska  52 , Mario Cazzola  28 , Hartmut Döhner  53 , Ayalew Tefferi  19

Affiliations

International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data

Daniel A Arber et al. Blood. 2022.

Abstract

The classification of myeloid neoplasms and acute leukemias was last updated in 2016 within a collaboration between the World Health Organization (WHO), the Society for Hematopathology, and the European Association for Haematopathology. This collaboration was primarily based on input from a clinical advisory committees (CACs) composed of pathologists, hematologists, oncologists, geneticists, and bioinformaticians from around the world. The recent advances in our understanding of the biology of hematologic malignancies, the experience with the use of the 2016 WHO classification in clinical practice, and the results of clinical trials have indicated the need for further revising and updating the classification. As a continuation of this CAC-based process, the authors, a group with expertise in the clinical, pathologic, and genetic aspects of these disorders, developed the International Consensus Classification (ICC) of myeloid neoplasms and acute leukemias. Using a multiparameter approach, the main objective of the consensus process was the definition of real disease entities, including the introduction of new entities and refined criteria for existing diagnostic categories, based on accumulated data. The ICC is aimed at facilitating diagnosis and prognostication of these neoplasms, improving treatment of affected patients, and allowing the design of innovative clinical trials.

PubMed Disclaimer

Similar articles

Cited by

References

    1. World Health Organization . World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Haematopietic and Lymphoid Tissues, 3rd ed. Lyon, France: IARC Press; 2001.
    1. World Health Organization . Classification of Tumours of Haematopoietic and Lymphoid Tissues. Lyon, France: IARC; 2008.
    1. Swerdlow SH, Campo E, Harris NL, et al., eds. WHO Classification fo Tumours of Haematopoietic and Lymphoid Tissues. Lyon, France: IARC; 2017.
    1. Harris NL, Jaffe ES, Diebold J, et al. . World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: report of the Clinical Advisory Committee meeting-Airlie House, Virginia, November 1997. J Clin Oncol. 1999;17(12):3835-3849. - PubMed
    1. Vardiman JW, Thiele J, Arber DA, et al. . The 2008 revision of the WHO classification of myeloid neoplasms and acute leukemia: rationale and important changes. Blood. 2009;114(5):937-951. - PubMed

MeSH terms