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Comprehending B-Cell Epitope Prediction to Develop Vaccines and Immunodiagnostics - PubMed

  • ️Sat Jan 01 2022

Comprehending B-Cell Epitope Prediction to Develop Vaccines and Immunodiagnostics

Salvador Eugenio C Caoili. Front Immunol. 2022.

No abstract available

Keywords: B-cell epitope prediction; B-cell epitopes; antipeptide antibodies; conformational disorder; immunodominance; peptide-based vaccines; protective immunity; surface accessibility.

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Conflict of interest statement

The author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1

Identification of plausible candidate vaccine peptide BCEs. Accessible disorder (AD) is realized for BCEs that are simultaneously both paratope-accessible and disordered (i.e., conformationally unconstrained) in both peptide-based immunogens and cognate native antigenic targets in situ (e.g., extracellular pathogen virulence factors). Immunodominant BCEs are identified empirically as they occur in peptide-based immunogens (e.g., using immunogenic carrier molecules and immunologic adjuvants) versus other contexts (e.g., in native antigenic targets comprising antigenic decoys).

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