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Research Progress on the Mechanisms of Polysaccharides against Gastric Cancer - PubMed

  • ️Sat Jan 01 2022

Review

Research Progress on the Mechanisms of Polysaccharides against Gastric Cancer

Liping Chen et al. Molecules. 2022.

Abstract

Gastric cancer is a common type of cancer that poses a serious threat to human health. Polysaccharides are important functional phytochemicals, and research shows that polysaccharides have good anti-gastric cancer effects. We collated all relevant literature published from 2000 to 2020 and found that more than 60 natural polysaccharides demonstrate anti-gastric cancer activity. At the present, the sources of these polysaccharides include fungi, algae, tea, Astragalus membranaceus, Caulis Dendrobii, and other foods and Chinese herbal medicines. By regulating various signaling pathways, including the PI3K/AKT, MAPK, Fas/FasL, Wnt/β-catenin, IGF-IR, and TGF-β signaling pathways, polysaccharides induce gastric cancer cell apoptosis, cause cell cycle arrest, and inhibit migration and invasion. In addition, polysaccharides can enhance the immune system and killing activity of immune cells in gastric cancer patients and rats. This comprehensive review covers the extraction, purification, structural characterization, and mechanism of plant and fungal polysaccharides against gastric cancer. We hope this review is helpful for researchers to design, research, and develop plant and fungal polysaccharides.

Keywords: anti-gastric cancer; fungi; mechanism; plants; polysaccharides.

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Conflict of interest statement

The authors state that there are no conflicts of interest.

Figures

Figure 1
Figure 1

Schematic representation of the extraction, purification, and characterization of polysaccharides against gastric cancer.

Figure 2
Figure 2

Tumor microenvironment and actions of PSK.

Figure 3
Figure 3

Scheme summarizing the polysaccharides’ signaling mechanisms of anti-gastric-cancer.

Figure 4
Figure 4

Schematic representation of the antitumor immune responses and actions of polysaccharides.

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