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Novel and Promising Strategies for Therapy of Post-Transplant Chronic GVHD - PubMed

  • ️Sat Jan 01 2022

Review

Novel and Promising Strategies for Therapy of Post-Transplant Chronic GVHD

Irina Kostareva et al. Pharmaceuticals (Basel). 2022.

Abstract

Despite the achievements that have increased viability after the transplantation of allogeneic hematopoietic stem cells (aHSCT), chronic graft-versus-host disease (cGVHD) remains the main cause of late complications and post-transplant deaths. At the moment, therapy alternatives demonstrate limited effectiveness in steroid-refractory illness; in addition, we have no reliable data on the mechanism of this condition. The lack of drugs of choice for the treatment of GVHD underscores the significance of the design of new therapies. Improved understanding of the mechanism of chronic GVHD has secured new therapy goals, and organized diagnostic recommendations and the development of medical tests have ensured a general language and routes for studies in this field. These factors, combined with the rapid development of pharmacology, have helped speed up the search of medicines and medical studies regarding chronic GVHD. At present, we can hope for success in curing this formidable complication. This review summarizes the latest clinical developments in new treatments for chronic GVHD.

Keywords: graft-versus-host disease; hematopoietic stem cell transplantation; novel agents; oligosaccharides.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1

Relationship between aGVHD and cGVHD pathogenesis.

Figure 2
Figure 2

Structures of active components of the drugs currently used for the treatment of GVHD or in drug candidates under development.

Figure 3
Figure 3

Two types of homofucose backbone chains in brown seaweed fucoidans (R depicts the places of potential attachment of carbohydrate substituents, sulfate, and acetyl groups) and the structure of fucoidan CF from C. flagelliformis seaweed.

Figure 4
Figure 4

The main structural features of fucosylated chondroitin sulfates from the sea cucumbers Massinium magnum, Apostichopus japonicus, Holothuria hilla, and Hemioedema spectabilis, as examples of natural polysaccharides of this type.

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