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Surgery for chronic arthropathy in people with haemophilia - PubMed

  • ️Sat Jan 01 2022

Review

Surgery for chronic arthropathy in people with haemophilia

Brian Chin et al. Cochrane Database Syst Rev. 2022.

Abstract

Background: Chronic arthropathy is a potentially debilitating complication for people with haemophilia - a genetic, X-linked, recessive bleeding disorder, characterised by the absence or deficiency of a clotting factor protein. Staging classifications, such as the Arnold-Hilgartner classification for haemophilic arthropathy of the knee, radiologically reflect the extent of knee joint destruction with underlying chronic synovitis. Management of this highly morbid disease process involves intensive prophylactic measures, and chemical or radioisotope synovectomy in its early stages. However, failure of non-surgical therapy in people with progression of chronic arthropathy often prompts surgical management, including synovectomy, joint debridement, arthrodesis, and arthroplasty, depending on the type of joint and extent of the damage. To date, management of people with mild to moderate chronic arthropathy from haemophilia remains controversial; there is no agreed standard treatment. Thus, the benefits and disadvantages of non-surgical and surgical management of mild to moderate chronic arthropathy in people with haemophilia needs to be systematically reviewed. OBJECTIVES: To assess the efficacy and safety of surgery for mild to moderate chronic arthropathy in people with haemophilia A or B.

Search methods: We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group's Coagulopathies Trials Register, CENTRAL, MEDLINE, Embase, CINAHL, and two trial registers to August 2022. We also handsearched relevant journals and conference abstract books.

Selection criteria: Randomized controlled trials (RCTs) and quasi-RCTs comparing surgery and non-surgical interventions, for any joint with chronic arthropathy, in people with haemophilia, who were at least 12 years old.

Data collection and analysis: The review authors did not identify any trials to include in this review.

Main results: The review authors did not identify any trials to include in this review.

Authors' conclusions: The review authors did not identify any trials to include in this review. Due to a lack of research in this particular area, we plan to update the literature search every two years, and will update review if any new evidence is reported. There is a need for a well-designed RCT that assesses the safety and efficacy of surgical versus non-surgical interventions for chronic arthropathy in people with haemophilia.

Copyright © 2022 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

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Conflict of interest statement

Brian Chin: none known

Ian Wee: none known

Nicholas Syn: none known

Gavin O'Neill: none known

Eng Soo Yap: none known

Pei Lin Koh: none known

Figures

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Study selection flow diagram

Update of

  • doi: 10.1002/14651858.CD013634

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References

References to studies excluded from this review

Gamba 1981 {published data only}
    1. Gamba G, Grignani G, Ascari E. Synoviorthesis versus synovectomy in the treatment of recurrent haemophilic haemarthrosis: long-term evaluation. Thrombosis and Haemostasis 1981;45(2):127-9. - PubMed
van den Berg 2003 {published data only}
    1. den Berg HM, Fischer K, Bom JG. Comparing outcomes of different treatment regimens for severe haemophilia. Haemophilia 2003;9(Suppl 1):27-31. - PubMed

Additional references

Abshire 2011
    1. Abshire T. Unraveling hemophilic arthropathy. Blood 2011;117(8):2302-03. - PubMed
Ahn 2020
    1. Ahn J, Yoo MC, Seo J, Park M, Jeong BO. Comparison of total ankle arthroplasty and ankle arthrodesis in end-stage hemophilic arthropathy. Foot Ankle International 2020;41(8):937-44. [DOI: 10.1177/1071100720929002] - DOI - PubMed
Atisook 2021
    1. Atisook R, Euasobhon P, Saengsanon A, Jensen MP. Validity and utility of four pain intensity measures for use in international research. Journal of Pain Research 2021;14:1129-39. [DOI: 10.2147/JPR.S303305] - DOI - PMC - PubMed
Aznar 2009
    1. Aznar JA, Lucia F, Abad-Franch L, Jimenez-Yuste V, Perez R, Batlle J, et al. Haemophilia in Spain. Haemophilia 2009;15(3):665-75. - PubMed
Barg 2016
    1. Barg A, Morris SC, Schneider SW, Phisitkul P, Saltzman CL. Surgical procedures in patients with haemophilic arthropathy of the ankle. Haemophilia 2016;22(3):156-76. - PubMed
Bieri 1990
    1. Bieri D, Reeve RA, Champion DG, Addicoat L, Ziegler JB. The Faces Pain Scale for the self-assessment of the severity of pain experienced by children: development, initial validation, and preliminary investigation for ratio scale properties. Pain 1990;41(2):139-50. [DOI: 10.1016/0304-3959(90)90018-9] - DOI - PubMed
Bluth 2013
    1. Bluth BE, Fong YJ, Houman JJ, Silva M, Luck JV Jr. Ankle fusion in patients with haemophilia. Haemophilia 2013;19(3):432-7. - PubMed
Bolton‐Maggs 2003
    1. Bolton-Maggs PH, Pasi KJ. Haemophilias A and B. Lancet 2003;362(9371):1801-9. - PubMed
Caraceni 2002
    1. Caraceni A, Cherny N, Fainsinger R, Kaasa S, Poulain P, Radbruch LD. Pain measurement tools and methods in clinical research in palliative care: recommendations of an expert working group of the European Association of Palliative Care. Journal of Pain Symptom Management 2002;23(3):239–55. [DOI: 10.1016/S0885-3924(01)00409-2] - DOI - PubMed
Chien 2013
    1. Chien CW, Bagraith KS, Khan A, Deen M, Strong J. Comparative responsiveness of verbal and numerical rating scales to measure pain intensity in patients with chronic pain. Journal of Pain 2013;14(2):1653-62. [DOI: 10.1016/j.jpain.2013.08.006] - DOI - PubMed
Collins 2010
    1. Collins P, Faradji A, Morfini M, Enriquez MM, Schwartz L. Efficacy and safety of secondary prophylactic vs. on-demand sucrose-formulated recombinant factor VIII treatment in adults with severe hemophilia A: results from a 13-month cross-over study. Journal of Thrombosis and Haemostasis 2010;8(1):83-9. - PubMed
Craddock 1948
    1. Craddock CG Jr, Fenniger LD, Simmons B. Hemophilia problem of surgical interventions for accompanying diseases: review of the literature and a report of case. Annals of Surgery 1948;128(5):888-903. - PMC - PubMed
Deeks 2022
    1. Deeks JJ, Higgins JP, Altman DG, editor(s). Chapter 10: Analysing data and undertaking meta-analyses. In: Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 6.3 (updated February 2022). Cochrane, 2022. Available from www.training.cochrane.org/handbook.
de Moerloose 2008
    1. Moerloose P, Urbancik W, den Berg HM, Richards M. A survey of adherence to haemophilia therapy in six European countries: results and recommendations. Haemophilia 2008;14(5):931-8. - PubMed
Eckers 2017
    1. Eckers F, Bauer DE, Hingsammer A, Sutter R, Brand B, Viehofer A, et al. Mid- to long-term results of total ankle replacement in patients with haemophilic arthropathy: a 10-year follow-up. Haemophilia 2017;24(2):307-15. - PubMed
EndNote 2013 [Computer program]
    1. EndNote. Version X9. Philadelphia, PA: Clarivate, 2013.
Gilbert 1993
    1. Gilbert MS. Prophylaxis: musculoskeletal evaluation. Seminars in Hematology 1993;30:3‐6. - PubMed
Gouw 2018
    1. Gouw SC, Timmer MA, Srivastava A, Kleijn P, Hilliard P, Peters M, et al. Measurement of joint health in persons with haemophilia: a systematic review of the measurement properties of haemophilia-specific instruments. Haemophilia 2019;25(1):e1-10. [DOI: 10.1111/hae.13631] - DOI - PMC - PubMed
GRADEpro GDT [Computer program]
    1. GRADEpro GDT. Version accessed 30 March 2019. Hamilton (ON): McMaster University (developed by Evidence Prime). Available at gradepro.org.
Gringeri 2011
    1. Gringeri A, Lundin B, Mackensen S, Mantovani L, Mannucci PM, ESPRIT Study Group. A randomized clinical trial of prophylaxis in children with hemophilia A (the ESPRIT study). Journal of Thrombosis and Haemostasis 2011;9(4):700-10. - PubMed
Haddad 2007
    1. Haddad SL, Coetzee JC, Estok R, Fahrbach K, Banel D, Nalysnyk L. Intermediate and long-term outcomes of total knee arthroplasty and ankle arthrodesis. A systematic review of the literature. Journal of Bone and Joint Surgery 2007;89(9):1899-905. - PubMed
Higgins 2002
    1. Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Statistics in Medicine 2002;21(11):1539-58. - PubMed
Higgins 2017
    1. Higgins JP, Altman DG, Sterne JA, editor(s). Chapter 8: Assessing risk of bias in included studies. In: Higgins JP, Churchill R, Chandler J, Cumpston MS, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.2 (updated June 2017). Cochrane, 2017. Available from training.cochrane.org/handbook/archive/v5.2.
Higgins 2022
    1. Higgins JP, Li T, Deeks JJ, editor(s). Chapter 6: Choosing effect measures and computing estimates of effect. In: Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 6.3 (updated February 2022). Cochrane, 2022. Available from www.training.cochrane.org/handbook.
Hill 2003
    1. Hill F, Ljung R. Third and fourth workshops of the European Paediatric Network for Haemophilia Management. Haemophilia 2003;9:223‐8. - PubMed
Hilliard 2006
    1. Hilliard P, Funk S, Zourikian N, Bergstrom BM, Bradley CS, McLimont M, et al. Hemophilia joint health score reliability study. Haemophilia 2006;12(5):518‐25. - PubMed
Hozo 2005
    1. Hozo SP, Djulbegovic B, Hozo I. Estimating the mean and variance from the median, range and the size of a sample. BMC Medical Research Methodology 2005;5:13. - PMC - PubMed
Iorio 2010
    1. Iorio A, Matino D, D'Amico R, Makris M. Recombinant factor VIIa concentrate versus plasma derived concentrates for the treatment of acute bleeding episodes in people with haemophilia and inhibitors. Cochrane Database of Systematic Reviews 2010, Issue 8. Art. No: CD004449. [DOI: 10.1002/14651858.CD004449.pub3] - DOI - PubMed
Jensen 2011
    1. Jensen MP, Karoly P. Self-report scales and procedures for assessing pain in adults. In: Turk DC, Melzack R, editors(s). Handbook of Pain Assessment. 3rd edition. New York: Guilford Press, 2011:19-44.
Leissinger 2011
    1. Leissinger C, Gringeri A, Antmen B, Berntorp E, Biasoli C, Carpenter S, et al. Anti-inhibitor coagulant complex prophylaxis in hemophilia with inhibitors. New England Journal of Medicine 2011;365(18):1684-92. - PubMed
Lobet 2014
    1. Lobet S, Hermans C, Lambert C. Optimal management of hemophilic arthropathy and hematomas. Journal of Blood Medicine 2014;5:207-18. - PMC - PubMed
Löfqvist 1997
    1. Löfqvist T, Nilsson IM, Berntorp E, Petterson H. Haemophilia prophylaxis in young patients – a long-term follow-up. Journal of Internal Medicine 1997;241(5):395-400. - PubMed
Luck 2004
    1. Luck JV, Silva M, Rodriguez-Merchan EC, Ghalambor N, Zahiri CA, Finn RS. Hemophilic arthropathy. Journal of the American Academy of Orthopaedic Surgeons 2004;12(4):234-45. - PubMed
Manco‐Johnson 2000
    1. Manco‐Johnson MJ, Nuss R, Funk S, Murphy J. Joint evaluation instruments for children and adults with haemophilia. Haemophilia 2000;6:649‐57. - PubMed
Manco‐Johnson 2004
    1. Manco-Johnson MJ, Pettersson H, Petrini P, Babyn PS, Bergstrom BM, Bradeley CS, et al. Physical therapy and imaging outcome measures in a hemophilia population treated with factor prophylaxis: current status and future directions. Haemophilia 2004;10(Suppl 4):88-93. - PubMed
Manco‐Johnson 2013
    1. Manco-Johnson MJ, Kempton CL, Reding MT, Lissitchkov T, Goranov S, Gercheva L, et al. Randomized, controlled, parallel-group trial of routine prophylaxis vs. on-demand treatment with sucrose-formulated recombinant factor VIII in adults with severe hemophilia A (SPINART). Journal of Thrombosis and Haemostasis 2013;11(6):1119-27. - PubMed
Marchesini 2021
    1. Marchesini E, Morfini M, Valentino L. Recent advances in the treatment of hemophilia: a review. Biologics 2021;15:221-35. [DOI: 10.2147/BTT.S252580] - DOI - PMC - PubMed
Melchiorre 2017
    1. Melchiorre D, Manetti M, Matucci-Cerinic M. Pathophysiology of hemophilic arthropathy. Journal of Clinical Medicine 2017;6(7):63. - PMC - PubMed
Oldenburg 2015
    1. Oldenburg J. Optimal treatment strategies for hemophilia: achievements and limitations of current prophylactic regimens. Blood 2015;125(13):2038-44. - PubMed
Page 2021
    1. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. PLoS Medicine 2021;18(3):e1003583. [DOI: 10.1371/journal.pmed.1003583] - DOI - PMC - PubMed
Page 2022
    1. Page MJ, Higgins JP, Sterne JA. Chapter 13: Assessing risk of bias due to missing results in a synthesis. In: Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 6.3 (updated February 2022). Cochrane, 2022. Available from www.training.cochrane.org/handbook.
Parmar 1998
    1. Parmar MK, Torri V, Steward L. Extracting summary statistics to perform meta-analysis of the published literature for survival endpoints. Statistics in Medicine 1998;17(24):2815-34. - PubMed
Pettersson 1980
    1. Pettersson H, Ahlberg A, Nilsson IM. A radiologic classification of hemophilic arthropathy. Clinical Orthopaedics and Related Research 1980;June 1(149):153-9. - PubMed
Pollack 2006
    1. Pollak E, Mühlan H, Mackensen S, Bullinger M, HAEMO-QOL GROUP. The Haemo-QoL Index: developing a short measure for health-related quality of life assessment in children and adolescents with haemophilia. Haemophilia 2006;12(4):384-92. [DOI: 10.1111/j.1365-2516.2006.01292.x] - DOI - PubMed
Rentz 2008
    1. Rentz A, Flood E, Altisent C, Bullinger M, Klamroth R, Garrido RP, et al. Cross-cultural development and psychometric evaluation of a patient-reported health-related quality of life questionnaire for adults with haemophilia. Haemophilia 2008;14(5):1023-34. [DOI: 10.1111/j.1365-2516.2008.01812.x] - DOI - PubMed
RevMan Web 2022 [Computer program]
    1. Review Manager Web (RevMan Web). Version 4.12.0. The Cochrane Collaboration, 2022. Available at revman.cochrane.org.
Richards 2010
    1. Richards M, Williams M, Chalmers E, Liesner R, Collins P, Vidler V, et al. A United Kingdom Haemophilia Centre Doctors' Organization guideline approved by the British Committee for Standards in Haematology: guideline on the use of prophylactic factor VIII concentrate in children and adults with severe haemophilia A. British Journal of Haematology 2010;149(4):498-507. - PubMed
Rodriguez‐Merchan 2010
    1. Rodriguez-Merchan EC. Musculoskeletal complications of hemophilia. Hospital for Special Surgery Journal 2010;6(1):37-42. - PMC - PubMed
Rodriguez‐Merchan 2015
    1. Rodriguez-Merchan EC, Valentino LA. Safety of radiation exposure after radiosynovectomy in paediatric patients with haemophilia. Haemophilia 2015;21(4):411–8. [DOI: 10.1111/hae.12668] - DOI - PubMed
Roosendaal 2008
    1. Roosendaal G, Jansen NW, Schutgens R, Lafeber FP. Haemophilic arthropathy: the importance of the earliest haemarthroses and consequences for treatment. Haemophilia 2008;14(Suppl 6):4-10. - PubMed
Schünemann 2022
    1. Schünemann HJ, Vist GE, Higgins JP, Santesso N, Deeks JJ, Glasziou P, et al. Chapter 15: Interpreting results and drawing conclusions. In: Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 6.3 (updated February 2022). Cochrane, 2022. Available from training.cochrane.org/handbook.
Solimeno 2017
    1. Solimeno LP, Pasta G. Knee and ankle arthroplasty in hemophilia. Journal of Clinical Medicine 2017;6(11):1-6. - PMC - PubMed
Song 2017
    1. Song SJ, Bae JK, Park CH, Yoo MC, Bae DK, Kim KI. Mid-term outcomes and complications of total knee arthroplasty in haemophilic arthropathy: a review of consecutive 131 knees between 2006 and 2015 in a single institute. Haemophilia 2017;24(2):299-306. - PubMed
Valentino 2012
    1. Valentino LA, Mamonov V, Hellmann A, Quon DV, Chybicka A, Schroth P, et al. A randomized comparison of two prophylaxis regimens and a paired comparison of on-demand and prophylaxis treatments in hemophilia A management. Journal of Thrombosis and Haemostasis 2012;10(3):359-67. - PMC - PubMed
Walsh 2009
    1. Walsh CE, Valentino LA. Factor VIII prophylaxis for adult patients with severe haemophilia A: results of a US survey of attitudes and practices. Haemophilia 2009;15(5):1014-21. - PubMed
Ware 1992
    1. Ware JE Jr, Sherbourne CD. The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Medical Care 1992;30(6):473-83. - PubMed
WFH 2012
    1. Srivastava A, Brewer AK, Mahlangu JN, Mauser-Bunschoten EP, Mulder K, Key NS. WFH guidelines for the management of hemophilia, 3rd edition. Haemophilia 2020;26(S6):1-158. - PubMed
WFH 2022
    1. World Federation of Hemophilia (WFH). About bleeding disorders — what are inhibitors? elearning.wfh.org/elearning-centres/inhibitors/ (accessed 15 July 2022).

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