pubmed.ncbi.nlm.nih.gov

Stem Cell Transplantation for Parkinson's Disease: Current Challenges and Perspectives - PubMed

  • ️Sat Jan 01 2022

Stem Cell Transplantation for Parkinson's Disease: Current Challenges and Perspectives

Xinlin Zeng et al. Aging Dis. 2022.

Abstract

Parkinson's disease is the second most common form of neurodegeneration, and it poses a major threat to the quality of life of older adults. Stem cell transplantation, which has attracted widespread attention from researchers, is a new treatment that is demonstrating excellent potential for treating Parkinson's disease. This paper introduces the advantages, disadvantages, and current research on the progress of using stem cells for Parkinson's disease; briefly describes the strategies for controlling the differentiation of stem cells into dopaminergic neurons in vitro; highlights how transplanted cells improve the loss of dopaminergic neurons by interacting with the inflammatory microenvironment in the brain; and proposes that future stem cell research focus on finely regulating the signal pathways that influence the directed differentiation of dopaminergic neurons to maintain an appropriate balance between the modulatory factors that affect the inflammatory microenvironment and clarify the interaction between neurons and neuroglia.

Keywords: Parkinson’s disease;; dopaminergic neuron; neurogenesis; neuroinflammation; stem cell transplantation.

copyright: © 2022 Zeng et al.

PubMed Disclaimer

Conflict of interest statement

Competing interests The authors declare that they have no competing interests.

Figures

Figure 1.
Figure 1.

The function and crosstalk of important signaling pathways in mDA neuron development. Schematic and simplified depiction of the components, function and crosstalk of the main signaling pathways involved in the generation and maintenance of mDA neurons in the mammalian embryo, BMP, FGF, SHH and WNT/β-catenin (from left to right).

Similar articles

Cited by

References

    1. Shen Y, Huang J, Liu L, Xu X, Han C, Zhang G, et al.. (2016). A Compendium of Preparation and Application of Stem Cells in Parkinson's Disease: Current Status and Future Prospects. Front Aging Neurosci, 8:117. - PMC - PubMed
    1. L'Episcopo F, Tirolo C, Caniglia S, Testa N, Morale MC, Serapide MF, et al.. (2014). Targeting Wnt signaling at the neuroimmune interface for dopaminergic neuroprotection/repair in Parkinson's disease. J Mol Cell Biol, 6:13-26 - PMC - PubMed
    1. Tansey MG, McCoy MK, Frank-Cannon TC (2007). Neuroinflammatory mechanisms in Parkinson's disease: potential environmental triggers, pathways, and targets for early therapeutic intervention. Exp Neurol, 208:1-25 - PMC - PubMed
    1. Miller RL, James-Kracke M, Sun GY, Sun AY (2009). Oxidative and inflammatory pathways in Parkinson's disease. Neurochem Res, 34:55-65 - PubMed
    1. Tetrud JW, Langston JW, Garbe PL, Ruttenber AJ (1989). Mild parkinsonism in persons exposed to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Neurology, 39:1483-1487 - PubMed

LinkOut - more resources