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Vaccine confidence among those living with allergy during the COVID pandemic (ACCORD): A scoping review - PubMed

Vaccine confidence among those living with allergy during the COVID pandemic (ACCORD): A scoping review

Ayel Luis R Batac et al. J Allergy Clin Immunol Glob. 2023 May.

Abstract

Background: Reports of allergic reactions to coronavirus disease 2019 (COVID-19) vaccines, coupled with an "infodemic" of misinformation, carry the potential to undermine confidence in the COVID-19 vaccines. However, no attempts have been made to comprehensively synthesize the literature on how allergic disease and fear of allergic reactions to the vaccines contribute to hesitancy.

Objectives: Our aim was to review the academic and gray literature on COVID-19 vaccine hesitancy and allergic reactions.

Methods: We searched 4 databases (CINAHL, PsycINFO, MEDLINE, and Embase) using a search strategy developed by content and methodologic experts. No restrictions were applied regarding COVID-19 vaccine type, country of study, or patient age. Eligible articles were restricted to 10 languages.

Results: Of the 1385 unique records retrieved from our search, 60 articles (4.3%) were included. Allergic reactions to the COVID-19 vaccine were rare but slightly more common in individuals with a history of allergic disease. A fifth of the studies (13 of 60 [22%]) discussed vaccine hesitancy due to possibility of an allergic reaction. Additionally, the present review identified research on details of vaccine-related anaphylaxis (eg, a mean and median [excluding clinical trial data] of 12.4 and 5 cases per million doses, respectively) and allergic reactions (eg, a mean and median [excluding clinical trial data] of 489 and 528 cases per million doses, respectively).

Conclusion: COVID-19 vaccine acceptance among individuals living with allergy and among those with no history of allergic disease may be affected by fear of an allergic reaction. Despite the low incidence of allergic reactions to the COVID-19 vaccine, fear of such reactions is one of the most commonly cited concerns reported in the literature.

Keywords: Allergy; CDC, US Centers for Disease Control and Prevention; COVID; COVID-19, Coronavirus disease 2019; OR, Odds ratio; PEG, Polyethylene glycol; VAERS, Vaccine Adverse Event Reporting System; anaphylaxis; hesitancy; scoping review; serious adverse events.

© 2023 The Author(s).

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Figures

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Fig 1

Preferred Reporting Items for Systematic Reviews and Meta-Analyses flow diagram demonstrating selection process of articles for the review.

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